Arrhythmias and electrocardiographic findings in Coronavirus disease 2019: A systematic review and meta-analysis.
Pacing Clin Electrophysiol
; 44(6): 1062-1074, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1199711
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) primarily causes lung infection, but recent studies have shown that cardiac involvement is associated with a worse prognosis.OBJECTIVES:
We conducted a systematic review and meta-analysis to examine the prevalence of cardiac arrhythmias detected by the electrocardiogram and their relationships with adverse outcomes in patients with COVID-19.METHODS:
PubMed and Google were searched for studies that reported on cardiac arrhythmias and/or examined the relationship between arrhythmias and adverse outcomes.RESULTS:
Thirty studies with 12,713 participants were included in the systematic review, and 28 studies (n = 12,499) in the meta-analysis. The mean age was 61.3 ± 16.8 years; 39.3% were female. In 25 studies with 7578 patients, the overall prevalence of cardiac arrhythmias was 10.3% (95% confidence interval [CI] 8.4%-12.3%). The most common arrhythmias documented during hospitalization were supraventricular arrhythmias (6.2%, 95% CI 4.4%-8.1%) followed by ventricular arrhythmias (2.5%, 95% CI 1.8%-3.1%). The incidence of cardiac arrhythmias was higher among critically ill patients (relative risk [RR] 12.1, 95% CI 8.5-17.3) and among non-survivors (RR 3.8, 95%, CI 1.7-8.7). Eight studies reported changes in the QT interval. The prevalence of QTc > 500 ms was 12.3% (95% CI 6.9%-17.8%). ST-segment deviation was reported in eight studies, with a pooled estimate of 8.7% (95% CI 7.3% to 10.0%).CONCLUSION:
Our meta-analysis showed that QTc prolongation, ST-segment deviation, and various other cardiac arrhythmias were observed in patients hospitalized with COVID-19. The presence of cardiac arrhythmias was associated with a worse prognosis.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Arrhythmias, Cardiac
/
Electrocardiography
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Pacing Clin Electrophysiol
Year:
2021
Document Type:
Article
Affiliation country:
Pace.14247
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