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Association of HLA-DRB1*09:01 with severe COVID-19.
Anzurez, Alitzel; Naka, Izumi; Miki, Shoji; Nakayama-Hosoya, Kaori; Isshiki, Mariko; Watanabe, Yusuke; Nakamura-Hoshi, Midori; Seki, Sayuri; Matsumura, Takayuki; Takano, Tomohiro; Onodera, Taishi; Adachi, Yu; Moriyama, Saya; Terahara, Kazutaka; Tachikawa, Natsuo; Yoshimura, Yoshihiro; Sasaki, Hiroaki; Horiuchi, Hiroshi; Miyata, Nobuyuki; Miyazaki, Kazuhito; Koga, Michiko; Ikeuchi, Kazuhiko; Nagai, Hiroyuki; Saito, Makoto; Adachi, Eisuke; Yotsuyanagi, Hiroshi; Kutsuna, Satoshi; Kawashima, Akira; Miyazato, Yusuke; Kinoshita, Noriko; Kouno, Chiyoko; Tanaka, Kensuke; Takahashi, Yoshimasa; Suzuki, Tadaki; Matano, Tetsuro; Ohashi, Jun; Kawana-Tachikawa, Ai.
  • Anzurez A; AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Naka I; Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
  • Miki S; Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan.
  • Nakayama-Hosoya K; AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Isshiki M; AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Watanabe Y; Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan.
  • Nakamura-Hoshi M; Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan.
  • Seki S; AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Matsumura T; AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Takano T; Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Onodera T; Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Adachi Y; Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Moriyama S; Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Terahara K; Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Tachikawa N; Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Yoshimura Y; Department of Infectious Diseases, Yokohama Municipal Citizens' Hospital, Kanagawa, Japan.
  • Sasaki H; Department of Infectious Diseases, Yokohama Municipal Citizens' Hospital, Kanagawa, Japan.
  • Horiuchi H; Department of Infectious Diseases, Yokohama Municipal Citizens' Hospital, Kanagawa, Japan.
  • Miyata N; Department of Infectious Diseases, Yokohama Municipal Citizens' Hospital, Kanagawa, Japan.
  • Miyazaki K; Department of Infectious Diseases, Yokohama Municipal Citizens' Hospital, Kanagawa, Japan.
  • Koga M; Department of Infectious Diseases, Yokohama Municipal Citizens' Hospital, Kanagawa, Japan.
  • Ikeuchi K; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Nagai H; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Saito M; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Adachi E; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Yotsuyanagi H; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Kutsuna S; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Kawashima A; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
  • Miyazato Y; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
  • Kinoshita N; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
  • Kouno C; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
  • Tanaka K; JR Tokyo General Hospital, Tokyo, Japan.
  • Takahashi Y; JR Tokyo General Hospital, Tokyo, Japan.
  • Suzuki T; Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Matano T; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Ohashi J; AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Kawana-Tachikawa A; Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
HLA ; 98(1): 37-42, 2021 07.
Article in English | MEDLINE | ID: covidwho-1199730
ABSTRACT
HLA-A, -C, -B, and -DRB1 genotypes were analyzed in 178 Japanese COVID-19 patients to investigate the association of HLA with severe COVID-19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA-DRB1*0901 and severe COVID-19 (odds ratio [OR], 3.62; 95% CI, 1.57-8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*0901 allele was more significantly associated with risk for severe COVID-19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HLA-DRB1 Chains / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: HLA Year: 2021 Document Type: Article Affiliation country: Tan.14256

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HLA-DRB1 Chains / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: HLA Year: 2021 Document Type: Article Affiliation country: Tan.14256