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Interstitial lung disease increases susceptibility to and severity of COVID-19.
Lee, Hyun; Choi, Hayoung; Yang, Bumhee; Lee, Sun-Kyung; Park, Tai Sun; Park, Dong Won; Moon, Ji-Yong; Kim, Tae-Hyung; Sohn, Jang Won; Yoon, Ho Joo; Kim, Sang-Heon.
  • Lee H; Division of Pulmonary Medicine and Allergy, Dept of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • Choi H; These three authors contributed equally to this work.
  • Yang B; Division of Pulmonary, Allergy and Critical Care Medicine, Dept of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
  • Lee SK; These three authors contributed equally to this work.
  • Park TS; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Chungbuk National University Hospital, Cheongju, Korea.
  • Park DW; These three authors contributed equally to this work.
  • Moon JY; Division of Pulmonary Medicine and Allergy, Dept of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • Kim TH; Dept of Mathematics, College of Natural Sciences, Hanyang University, Seoul, Korea.
  • Sohn JW; Division of Pulmonary Medicine and Allergy, Dept of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • Yoon HJ; Division of Pulmonary Medicine and Allergy, Dept of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • Kim SH; Division of Pulmonary Medicine and Allergy, Dept of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Eur Respir J ; 58(6)2021 12.
Article in English | MEDLINE | ID: covidwho-1199896
ABSTRACT

BACKGROUND:

There are limited data regarding the relationship between interstitial lung disease (ILD) and the natural course of COVID-19. In this study, we investigate whether patients with ILD are more susceptible to COVID-19 than those without ILD and evaluate the impact of ILD on disease severity in patients with COVID-19.

METHODS:

A nationwide cohort of patients with COVID-19 (n=8070) and a 115 age-, sex- and residential area-matched cohort (n=121 050) were constructed between 1 January 2020 and 30 May 2020 in Korea. We performed a nested case-control study to compare the proportions of patients with ILD between the COVID-19 cohort and the matched cohort. Using the COVID-19 cohort, we also evaluated the risk of severe COVID-19 in patients with ILD versus those without ILD.

RESULTS:

The proportion of patients with ILD was significantly higher in the COVID-19 cohort than in the matched cohort (0.8% versus 0.4%; p<0.001). The odds of having ILD was significantly higher in the COVID-19 cohort than in the matched cohort (adjusted OR 2.02, 95% CI 1.54-2.61). Among patients in the COVID-19 cohort, patients with ILD were more likely to have severe COVID-19 than patients without ILD (47.8% versus 12.6%), including mortality (13.4% versus 2.8%) (all p<0.001). The risk of severe COVID-19 was significantly higher in patients with ILD than in those without ILD (adjusted OR 2.23, 95% CI 1.24-4.01).

CONCLUSION:

The risks of COVID-19 and severe presentation were significantly higher in patients with ILD than in those without ILD.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Diseases, Interstitial / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Diseases, Interstitial / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2021 Document Type: Article