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Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium.
Jacobs, Merel; Lahousse, Lies; Van Eeckhoutte, Hannelore P; Wijnant, Sara R A; Delanghe, Joris R; Brusselle, Guy G; Bracke, Ken R.
  • Jacobs M; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
  • Lahousse L; Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
  • Van Eeckhoutte HP; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
  • Wijnant SRA; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
  • Delanghe JR; Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
  • Brusselle GG; Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Bracke KR; Laboratory of Clinical Chemistry, Dept of Diagnostic Sciences, Ghent University, Ghent, Belgium.
ERJ Open Res ; 7(2)2021 Apr.
Article in English | MEDLINE | ID: covidwho-1199897
ABSTRACT
Increased protein levels of ACE2 in alveolar epithelium of subjects who are homozygous for the ACE1 insertion of rs1799752 might facilitate host cell entry of #SARSCoV2 and explain the higher prevalence of #COVID19 in certain regions https//bit.ly/3k6aAE8.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study Language: English Year: 2021 Document Type: Article Affiliation country: 23120541.00940-2020

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study Language: English Year: 2021 Document Type: Article Affiliation country: 23120541.00940-2020