Treating Acute Leukemia During the COVID-19 Pandemic in an Environment With Limited Resources: A Multicenter Experience in Four Latin American Countries.
JCO Glob Oncol
; 7: 577-584, 2021 04.
Article
in English
| MEDLINE | ID: covidwho-1199957
ABSTRACT
PURPOSE:
The COVID-19 pandemic is a colossal challenge for global health; nonetheless, specific subgroups face considerably higher risks for infection and mortality. Among patients with malignant diseases, those with hematologic neoplasms are at a higher risk for poor outcomes. The objective of this study was to register treatment modifications associated with the COVID-19 pandemic and their short-term consequences in Latin America.METHODS:
Multicenter, prospective, observational, cohort study including patients older than 14 years from 14 centers in four countries (Mexico, Peru, Guatemala, and Panama) who had a confirmed diagnosis of acute leukemia, and who were undergoing active treatment since the first COVID-19 case in each country until the cutoff on July 15, 2020.RESULTS:
We recruited 635 patients. Treatment modifications because of the COVID-19 pandemic were reported in 40.8% of cases. The main reason for such modifications was logistic issues (55.0%) and the most frequent modification was chemotherapy delay (42.0%). A total of 13.1% patients developed COVID-19 disease, with a mortality of 37.7%. Several factors were identified as independently associated with mortality, including a diagnosis of acute myeloid leukemia (odds ratio 2.38 [95% CI, 1.47 to 3.84]; P < .001), while the use of telemedicine was identified as a protective factor (odds ratio 0.36 [95% CI, 0.18 to 0.82]; P = .014).CONCLUSION:
These results highlight the collateral damage of COVID-19 in oncology patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Leukemia, Myeloid
/
SARS-CoV-2
/
COVID-19
/
Medical Oncology
Type of study:
Cohort study
/
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Country/Region as subject:
Central America
/
South America
/
Guatemala
/
Mexico
/
Panama
/
Peru
Language:
English
Journal:
JCO Glob Oncol
Year:
2021
Document Type:
Article
Affiliation country:
Go.20.00620
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