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Detection of the new SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in five SARS-CoV-2 rapid antigen tests (RATs), Germany, March 2021.
Jungnick, Sabrina; Hobmaier, Bernhard; Mautner, Lena; Hoyos, Mona; Haase, Maren; Baiker, Armin; Lahne, Heidi; Eberle, Ute; Wimmer, Clara; Hepner, Sabrina; Sprenger, Annika; Berger, Carola; Dangel, Alexandra; Wildner, Manfred; Liebl, Bernhard; Ackermann, Nikolaus; Sing, Andreas; Fingerle, Volker.
  • Jungnick S; These authors contributed equally to this work.
  • Hobmaier B; Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Mautner L; These authors contributed equally to this work.
  • Hoyos M; Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Haase M; Unit of molecular biologic analytics and biogenetics, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Baiker A; Unit of molecular biologic analytics and biogenetics, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Lahne H; Unit of molecular biologic analytics and biogenetics, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Eberle U; Unit of molecular biologic analytics and biogenetics, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Wimmer C; Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Hepner S; Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Sprenger A; Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Berger C; Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Dangel A; Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Wildner M; Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Liebl B; Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.
  • Ackermann N; Bavarian State Institute of Health, Oberschleißheim, Germany.
  • Sing A; Ludwig Maximilians-Universität, Munich, Germany.
  • Fingerle V; Bavarian State Institute of Health, Oberschleißheim, Germany.
Euro Surveill ; 26(16)2021 04.
Article in English | MEDLINE | ID: covidwho-1200054
ABSTRACT
SARS-CoV-2 variants of concern (VOC) should not escape molecular surveillance. We investigated if SARS-CoV-2 rapid antigen tests (RATs) could detect B.1.1.7 and B.1.351 VOCs in certain laboratory conditions. Infectious cell culture supernatants containing B.1.1.7, B.1.351 or non-VOC SARS-CoV-2 were respectively diluted both in DMEM and saliva. Dilutions were analysed with Roche, Siemens, Abbott, nal von minden and RapiGEN RATs. While further studies with appropriate real-life clinical samples are warranted, all RATs detected B.1.1.7 and B.1.351, generally comparable to non-VOC strain.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Topics: Variants Limits: Humans Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Topics: Variants Limits: Humans Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article