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IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection.
Quinti, Isabella; Mortari, Eva Piano; Fernandez Salinas, Ane; Milito, Cinzia; Carsetti, Rita.
  • Quinti I; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Mortari EP; Department of Laboratory Medicine, Research Area Multimodal Medicine, Diagnostic Immunology and Research Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
  • Fernandez Salinas A; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Milito C; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Carsetti R; Department of Laboratory Medicine, Research Area Multimodal Medicine, Diagnostic Immunology and Research Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Front Cell Infect Microbiol ; 11: 655896, 2021.
Article in English | MEDLINE | ID: covidwho-1200086
ABSTRACT
A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It protects the epithelial barriers from pathogens and modulates excessive immune responses in inflammatory diseases. An early SARS-CoV-2 specific humoral response is dominated by IgA antibodies responses greatly contributing to virus neutralization. The lack of anti-SARS-Cov-2 IgA and secretory IgA (sIgA) might represent a possible cause of COVID-19 severity, vaccine failure, and possible cause of prolonged viral shedding in patients with Primary Antibody Deficiencies, including patients with Selective IgA Deficiency. Differently from other primary antibody deficiency entities, Selective IgA Deficiency occurs in the vast majority of patients as an asymptomatic condition, and it is often an unrecognized, Studies are needed to clarify the open questions raised by possible consequences of a lack of an IgA response to SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin A / IgA Deficiency / COVID-19 / Antibodies, Viral Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: Fcimb.2021.655896

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin A / IgA Deficiency / COVID-19 / Antibodies, Viral Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: Fcimb.2021.655896