Determinants of mortality of patients with COVID-19 in Wuhan, China: a case-control study.
Ann Palliat Med
; 10(4): 3937-3950, 2021 Apr.
Article
in English
| MEDLINE | ID: covidwho-1200419
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) has resulted in an overwhelmed challenge to the healthcare system worldwide.METHODS:
A case-control study of COVID-19 patients in Wuhan Third Hospital was conducted. 96 deceased COVID-19 patients and 230 discharged patients were included as the case group and control group, respectively. Demographic, epidemiological, clinical and laboratory variables on admission were collected from electronic medical records. Univariate and multivariate logistic regression were adopted to investigate the independent predictors of mortality. A nomogram was formed for predicting the mortality risk.RESULTS:
The multivariate stepwise logistic model demonstrated that age of 60+ years (OR =4.426, 95% CI 1.955-10.019), comorbidity of cerebrovascular disease (OR =7.084, 95% CI 1.545-32.471), white blood cell (WBC) count >9.5×109/L (OR =7.308, 95% CI 1.650-32.358), platelet count <125×109/L (OR =5.128, 95% CI 2.157-12.191), aspartate aminotransferase (AST) >40 U/L (OR =2.554, 95% CI 1.253-5.206), cystatin C >1.1 mg/L (OR =4.132, 95% CI 2.118-8.059), C reactive protein (CRP) ≥100 mg/L (OR =2.830, 95% CI 1.311-6.109), creatine kinase isoenzymes (CK-MB) >24 U/L (OR =6.015, 95% CI 2.119-17.07) and D-dimer >5 µg/L (OR =4.917, 95% CI 1.619-14.933) were independent predictors of mortality of COVID-19 patients. The nomogram demonstrated a well discriminatory accuracy for mortality prediction with a C-index of 0.903.CONCLUSIONS:
The determinants identified may help to determine patients at high risk of death at an early stage and guide the optimal treatment.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Journal:
Ann Palliat Med
Year:
2021
Document Type:
Article
Affiliation country:
Apm-20-2107
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