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Efficacy and safety of Reduning injection in the treatment of COVID-19: a randomized, multicenter clinical study.
Xu, Xiaolong; Zhang, Junhua; Zheng, Wenke; Yang, Zifeng; Zhao, Xuegong; Wang, Changfeng; Su, Hongzheng; Zhao, Li; Xue, Leyang; Hu, Fen; Xu, Xiaohong; Wen, Minyong; Liao, Jiong; Zeng, Zhaohai; Wang, Liping; Zeng, Jiaqing; Guo, Yuhong; Li, Bo; Liu, Qingquan.
  • Xu X; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing, China.
  • Zhang J; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Zheng W; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Yang Z; Guangzhou Institute of Respiratory Diseases, Guangzhou, China.
  • Zhao X; The Third Hospital of Yichang, Yichang, China.
  • Wang C; Huanggang Central Hospital, Huanggang, China.
  • Su H; People's Hospital of Zaoyang, Zaoyang, China; .
  • Zhao L; The Fourth People's Hospital of Lianyungang, Lianyungang, China; .
  • Xue L; Huai'an Fourth People's Hospital, Huai'an, China.
  • Hu F; The First People's Hospital of Jiangxia District of Wuhan City, Wuhan, China; .
  • Xu X; People's Hospital of Hanchuan, Hanchuan, China.
  • Wen M; The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Liao J; People's Hospital of Laibin, Laibin, China.
  • Zeng Z; People's Hospital of Guangshan County, Xinyang, China; .
  • Wang L; The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
  • Zeng J; The First People's Hospital of Laohekou, Laohekou, China.
  • Guo Y; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing, China.
  • Li B; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing, China.
  • Liu Q; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing, China.
Ann Palliat Med ; 10(5): 5146-5155, 2021 May.
Article in English | MEDLINE | ID: covidwho-1200420
Semantic information from SemMedBD (by NLM)
1. treatment program TREATS Pneumonia
Subject
treatment program
Predicate
TREATS
Object
Pneumonia
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. treatment program TREATS Pneumonia
Subject
treatment program
Predicate
TREATS
Object
Pneumonia
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

BACKGROUND:

Reduning injection is a traditional Chinese medicine (TCM) with known efficacy against a variety of viral infections, but there is no data about its efficacy against coronavirus disease 2019 (COVID-19).

METHODS:

To explore the efficacy and safety of Reduning injection in the treatment of COVID-19, a randomized, open-labeled, multicenter, controlled trial was conducted from 12 general hospitals between 2020.02.06 and 2020.03.23. Patients with COVID-19 who met the diagnostic criteria of the "Diagnosis and Treatment Program for Novel Coronavirus Infection Pneumonia (Trial Fifth Edition)". Patients were randomized to routine treatment with or without Reduning injection (20 mL/day for 14 days) (ChiCTR2000029589). The primary endpoint was the rate of achieving clinical symptom recovery on day 14 of treatment.

RESULTS:

There were 77 and 80 participants in the Reduning and control groups. The symptom resolution rate at 14 days was higher in the Reduning injection than in controls [full-analysis set (FAS) 84.4% vs. 60.0%, P=0.0004]. Compared with controls, the Reduning group showed shorter median time to resolution of the clinical symptoms (143 vs. 313.5 h, P<0.001), shorter to nucleic acid test turning negative (146.5 vs. 255.5 h, P<0.001), shorter hospital stay (14.1 vs. 18.1 days, P<0.001), and shorter time to defervescence (29 vs. 71 h, P<0.001). There was no difference in AEs (3.9% vs. 8.8%, P=0.383).

CONCLUSIONS:

This preliminary trial suggests that Reduning injection might be effective and safe in patients with symptomatic COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Drugs, Chinese Herbal / COVID-19 Type of study: Controlled clinical trial / Diagnostic study / Observational study / Randomized controlled trials Topics: Traditional medicine Limits: Humans Language: English Journal: Ann Palliat Med Year: 2021 Document Type: Article Affiliation country: Apm-20-2121

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drugs, Chinese Herbal / COVID-19 Type of study: Controlled clinical trial / Diagnostic study / Observational study / Randomized controlled trials Topics: Traditional medicine Limits: Humans Language: English Journal: Ann Palliat Med Year: 2021 Document Type: Article Affiliation country: Apm-20-2121