Antibiotic use in patients with Coronavirus disease 2019 (COVID-19): outcomes and associated factors.
Acta Clin Belg
; 77(3): 579-587, 2022 Jun.
Article
in English
| MEDLINE | ID: covidwho-1201073
ABSTRACT
OBJECTIVES:
To characterise the factors, outcomes and infections associated with antibiotic use in COVID-19 patients.METHODS:
Records of patients with RT-PCR-confirmed COVID-19, hospitalized at the CHU Charleroi (Belgium) between 11 March and 3 May 3 2020, were retrospectively reviewed. Factors associated with antibiotic treatment, outcomes and bacterial infections were analysed.RESULTS:
Among the 164 hospitalized COVID-19 patients (median age 60.5 years [IQR] 46-79), twenty-five (15.2%) were admitted to the ICU. Twenty-six (15.9%) died in the hospital. One hundred (61%) received antibiotic treatment. Combination therapies with macrolides were more common in the early part of the study period (26/67, 38.8%). Twenty-eight patients (17.1%) had a confirmed infection, mostly of the urinary tract (18/28, 64.3%). Only 2 (1.2%) had a documented respiratory coinfection. Six of the 7 ICU infections (85.7%) were superinfections. Gram-negative bacteria were most frequently isolated. In multivariate analysis, six factors were associated with antibiotic use being hospitalized in the ICU (OR 4.59; 95% CI 1.07-19.71), age > 65 years (OR 4.16; 95% CI 1.72-10.05), arrival from a nursing home (OR 4.59; 95% CI 1.11-19.71), diabetes (OR 4.35; 95% CI 1.26-14.93), bilateral consolidation on chest CT (OR 9.92; 95% CI 2.40-41.06) and a C-reactive protein level > 60 mg/L (OR2.46; 95% CI 1.13-5.37). Antibiotic treatment did not reduce the length of stay or the mortality rate.CONCLUSION:
Antibiotics have been overused during the COVID-19 pandemic, despite a low rate of coinfections . Integrating the antimicrobial stewardship (AMS) programme into the COVID-19 response is essential.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coinfection
/
COVID-19 Drug Treatment
Type of study:
Observational study
Limits:
Aged
/
Humans
/
Middle aged
Language:
English
Journal:
Acta Clin Belg
Year:
2022
Document Type:
Article
Affiliation country:
17843286.2021.1916300
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