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COVID-19 During Development: A Matter of Concern.
Saavedra, Lucas Paulo Jacinto; Prates, Kelly Valério; Gonçalves, Gessica Dutra; Piovan, Silvano; Matafome, Paulo; Mathias, Paulo Cezar de Freitas.
  • Saavedra LPJ; Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Brazil.
  • Prates KV; Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Brazil.
  • Gonçalves GD; Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Brazil.
  • Piovan S; Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Brazil.
  • Matafome P; Institute of Physiology and Institute of Clinical and Biomedical Research, Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
  • Mathias PCF; Coimbra Health School, ESTeSC, Instituto Politécnico de Coimbra, Coimbra, Portugal.
Front Cell Dev Biol ; 9: 659032, 2021.
Article in English | MEDLINE | ID: covidwho-1201299
ABSTRACT
A new infectious disease, COVID-19, has spread around the world. The most common symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are cough and fever, but severe cases can develop acute respiratory distress syndrome. The main receptor for SARS-CoV-2 in human tissue is angiotensin-converting enzyme 2, and the lungs, heart, and kidneys are the most affected organs. Besides the inflammatory process and tissue damage, the presence of a cytokine "storm" has been related to a higher mortality rate. Other infectious viral diseases, such as Zika, chikungunya, and influenza, were associated with complications in pregnant women, such as growth restriction, malformation, preterm birth, low birth weight, miscarriage, and death, although they can also cause developmental disorders in infants and adolescents. Evidence points out that stressors during pregnancy and infancy may lead to the development of obesity, diabetes, and cardiovascular disease. Therefore, we hypothesize that COVID-19 infection during the critical phases of development can program the individual to chronic diseases in adulthood. It is important that COVID-19 patients receive proper monitoring as a way to avoid expensive costs to public health in the future.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Cell Dev Biol Year: 2021 Document Type: Article Affiliation country: Fcell.2021.659032

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Cell Dev Biol Year: 2021 Document Type: Article Affiliation country: Fcell.2021.659032