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Herpes Simplex Keratitis in Patients with SARS-CoV-2 Infection: A Series of Five Cases.
Majtanova, Nora; Kriskova, Petra; Keri, Petra; Fellner, Zlatica; Majtan, Juraj; Kolar, Petr.
  • Majtanova N; Department of Ophthalmology of Slovak Medical University and University Hospital in Bratislava, Antolska 11, 851 07 Bratislava, Slovakia.
  • Kriskova P; Faculty of Medicine, Slovak Medical University, Limbova 12, 833 03 Bratislava, Slovakia.
  • Keri P; Department of Ophthalmology of Slovak Medical University and University Hospital in Bratislava, Antolska 11, 851 07 Bratislava, Slovakia.
  • Fellner Z; Department of Ophthalmology of Slovak Medical University and University Hospital in Bratislava, Antolska 11, 851 07 Bratislava, Slovakia.
  • Majtan J; Department of Ophthalmology of Slovak Medical University and University Hospital in Bratislava, Antolska 11, 851 07 Bratislava, Slovakia.
  • Kolar P; Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska cesta 21, 845 51 Bratislava, Slovakia.
Medicina (Kaunas) ; 57(5)2021 Apr 24.
Article in English | MEDLINE | ID: covidwho-1201634
Semantic information from SemMedBD (by NLM)
1. Keratiti PROCESS_OF C0030705
Subject
Keratiti
Predicate
PROCESS_OF
Object
C0030705
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Simplexvirus CAUSES Blindness
Subject
Simplexvirus
Predicate
CAUSES
Object
Blindness
4. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
5. Severe disease PROCESS_OF Patients
Subject
Severe disease
Predicate
PROCESS_OF
Object
Patients
6. Herpesviridae PROCESS_OF Patients
Subject
Herpesviridae
Predicate
PROCESS_OF
Object
Patients
7. Keratiti COEXISTS_WITH C0683521
Subject
Keratiti
Predicate
COEXISTS_WITH
Object
C0683521
8. Laboratory Procedures USES fluorescein
Subject
Laboratory Procedures
Predicate
USES
Object
fluorescein
9. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
10. Clear corneas PROCESS_OF Patients
Subject
Clear corneas
Predicate
PROCESS_OF
Object
Patients
11. Eye LOCATION_OF Disease
Subject
Eye
Predicate
LOCATION_OF
Object
Disease
12. COVID-19 PREDISPOSES Keratiti
Subject
COVID-19
Predicate
PREDISPOSES
Object
Keratiti
13. Keratitis, Herpetic PROCESS_OF Patients
Subject
Keratitis, Herpetic
Predicate
PROCESS_OF
Object
Patients
14. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
15. Simplexvirus CAUSES Blindness
Subject
Simplexvirus
Predicate
CAUSES
Object
Blindness
16. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
17. Severe disease PROCESS_OF Patients
Subject
Severe disease
Predicate
PROCESS_OF
Object
Patients
18. Herpesviridae PROCESS_OF Patients
Subject
Herpesviridae
Predicate
PROCESS_OF
Object
Patients
19. Keratitis, Herpetic COEXISTS_WITH Patient Physiological Condition
Subject
Keratitis, Herpetic
Predicate
COEXISTS_WITH
Object
Patient Physiological Condition
20. Laboratory Procedures USES fluorescein
Subject
Laboratory Procedures
Predicate
USES
Object
fluorescein
21. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
22. Clear corneas PROCESS_OF Patients
Subject
Clear corneas
Predicate
PROCESS_OF
Object
Patients
23. Eye LOCATION_OF Disease
Subject
Eye
Predicate
LOCATION_OF
Object
Disease
24. COVID-19 PREDISPOSES Keratitis, Herpetic
Subject
COVID-19
Predicate
PREDISPOSES
Object
Keratitis, Herpetic
ABSTRACT
Herpes simplex virus type 1 (HSV-1) is a leading cause of infectious blindness worldwide. Most of the initial infection cases manifest as acute epithelial keratitis. Reactivation of herpesviruses is common in critically ill patients, including patients with severe Coronavirus disease (COVID-19). However, the data on COVID-19-related ocular infections is sparse, despite recent observations that more than 30% of COVID-19-infected patients had ocular manifestations. We report five cases of HSV-1 keratitis in COVID-19 patients. In total, five COVID-19 patients underwent ophthalmic examination, showing similar symptoms, including photophobia, tearing, decreased vision, eye redness, and pain. After initial assessment, tests of visual acuity and corneal sensitivity, a fluorescein staining test, and complete anterior and posterior segment examinations were performed. A diagnosis of HSV-1 keratitis was confirmed in all cases. Therapy was initiated using a local and systemic antiviral approach together with local antibiotic and mydriatic therapy. The complete reduction of keratitis symptoms and a clear cornea was achieved in all patients within 2 weeks. SARS-CoV-2 infection may be a risk factor for developing HSV-1 keratitis, or it may act as a potential activator of this ocular disease.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Keratitis, Herpetic / Herpesvirus 1, Human / COVID-19 Subject: Keratitis, Herpetic / Herpesvirus 1, Human / COVID-19 Type of study: Case report / Diagnostic study / Risk factors Language: English Clinical aspect: Diagnosis / Etiology / Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Keratitis, Herpetic / Herpesvirus 1, Human / COVID-19 Subject: Keratitis, Herpetic / Herpesvirus 1, Human / COVID-19 Type of study: Case report / Diagnostic study / Risk factors Language: English Clinical aspect: Diagnosis / Etiology / Therapy Year: 2021
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