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Longitudinal Analysis and Comparison of Six Serological Assays up to Eight Months Post-COVID-19 Diagnosis.
Aubry, Aurélien; Demey, Baptiste; François, Catherine; Duverlie, Gilles; Castelain, Sandrine; Helle, François; Brochot, Etienne.
  • Aubry A; Department of Virology, Amiens University Medical Center, 80000 Amiens, France.
  • Demey B; Resistant Infectious Agents and Chemotherapy Research Unit, AGIR UR4294, Jules Verne University of Picardie, 80000 Amiens, France.
  • François C; Department of Virology, Amiens University Medical Center, 80000 Amiens, France.
  • Duverlie G; Resistant Infectious Agents and Chemotherapy Research Unit, AGIR UR4294, Jules Verne University of Picardie, 80000 Amiens, France.
  • Castelain S; Department of Virology, Amiens University Medical Center, 80000 Amiens, France.
  • Helle F; Resistant Infectious Agents and Chemotherapy Research Unit, AGIR UR4294, Jules Verne University of Picardie, 80000 Amiens, France.
  • Brochot E; Department of Virology, Amiens University Medical Center, 80000 Amiens, France.
J Clin Med ; 10(9)2021 Apr 21.
Article in English | MEDLINE | ID: covidwho-1201827
ABSTRACT

BACKGROUND:

There is much data available concerning the initiation of the immune response after SARS-CoV-2 infection, but long-term data are scarce.

METHODS:

We thus longitudinally evaluated and compared the total and neutralizing immune response of 61 patients to SARS-CoV-2 infection up to eight months after diagnosis by RT-PCR using several commercial assays.

RESULTS:

Among the 208 samples tested, the percentage of seropositivity was comparable between assays up to four months after diagnosis and then tended to be more heterogeneous between assays (p < 0.05). The percentage of patients with a neutralizing titer decreased from 82% before two months postdiagnosis to 57% after six months. This decrease appeared to be more marked for patients under 65 years old and those not requiring hospitalization. The percentage of serology reversion at 6 months was from 11% with the WANTAI total assay to over 39% with the ABBOTT IgG assay. The neutralizing antibody titers decreased in parallel with the decrease of total antibody titers, with important heterogeneity between assays.

CONCLUSIONS:

In conclusion, serological tests show equivalent sensitivity in the first months after the diagnosis of SARS-CoV-2 infection, but their performance later, postinfection, must be considered when interpreting the results.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Long Covid Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10091815

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Long Covid Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10091815