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PIMS-TS, the New Paediatric Systemic Inflammatory Disease Related to Previous Exposure to SARS-CoV-2 Infection-"Rheumatic Fever" of the 21st Century?
Opoka-Winiarska, Violetta; Grywalska, Ewelina; Rolinski, Jacek.
  • Opoka-Winiarska V; Department of Paediatric Pulmonology and Rheumatology, Medical University of Lublin, Gebali 6, 20-093 Lublin, Poland.
  • Grywalska E; Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Chodzki 4a Street, 20-093 Lublin, Poland.
  • Rolinski J; Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Chodzki 4a Street, 20-093 Lublin, Poland.
Int J Mol Sci ; 22(9)2021 Apr 26.
Article in English | MEDLINE | ID: covidwho-1202016
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus COEXISTS_WITH pediatric inflammatory multisystem syndrome
Subject
2019 novel coronavirus
Predicate
COEXISTS_WITH
Object
pediatric inflammatory multisystem syndrome
2. pediatric multisystem inflammatory diseas PROCESS_OF C0030705
Subject
pediatric multisystem inflammatory diseas
Predicate
PROCESS_OF
Object
C0030705
3. CD69 protei ASSOCIATED_WITH C0035436
Subject
CD69 protei
Predicate
ASSOCIATED_WITH
Object
C0035436
4. Abnormal host response ASSOCIATED_WITH Rheumatic Fever
Subject
Abnormal host response
Predicate
ASSOCIATED_WITH
Object
Rheumatic Fever
5. Abnormal host response ASSOCIATED_WITH pediatric multisystem inflammatory diseas
Subject
Abnormal host response
Predicate
ASSOCIATED_WITH
Object
pediatric multisystem inflammatory diseas
6. Current Therapy TREATS pediatric multisystem inflammatory diseas
Subject
Current Therapy
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TREATS
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pediatric multisystem inflammatory diseas
7. 2019 novel coronavirus NEG_PROCESS_OF Child
Subject
2019 novel coronavirus
Predicate
NEG_PROCESS_OF
Object
Child
8. 2019 novel coronavirus COEXISTS_WITH pediatric inflammatory multisystem syndrome
Subject
2019 novel coronavirus
Predicate
COEXISTS_WITH
Object
pediatric inflammatory multisystem syndrome
9. pediatric multisystem inflammatory disease, COVID-19 related PROCESS_OF Patients
Subject
pediatric multisystem inflammatory disease, COVID-19 related
Predicate
PROCESS_OF
Object
Patients
10. CD69 protein, human|CD69 ASSOCIATED_WITH Rheumatic Fever
Subject
CD69 protein, human|CD69
Predicate
ASSOCIATED_WITH
Object
Rheumatic Fever
11. Abnormal host response ASSOCIATED_WITH Rheumatic Fever
Subject
Abnormal host response
Predicate
ASSOCIATED_WITH
Object
Rheumatic Fever
12. Abnormal host response ASSOCIATED_WITH pediatric multisystem inflammatory disease, COVID-19 related
Subject
Abnormal host response
Predicate
ASSOCIATED_WITH
Object
pediatric multisystem inflammatory disease, COVID-19 related
13. Current Therapy TREATS pediatric multisystem inflammatory disease, COVID-19 related
Subject
Current Therapy
Predicate
TREATS
Object
pediatric multisystem inflammatory disease, COVID-19 related
14. 2019 novel coronavirus NEG_PROCESS_OF Child
Subject
2019 novel coronavirus
Predicate
NEG_PROCESS_OF
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Child
ABSTRACT
Paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS) is a new systemic inflammatory disease that mainly affects children. Its course in many features resembles that of acute rheumatic fever (ARF). Therefore, it is interesting that the experiences with ARF can be used in the management of patients with PIMS-TS. The aim of the article is to analyse the current data on PIMS-TS in relation to ARF. PIMS-TS and ARF are associated with an abnormal immune response to specific pathogens (SARS-CoV-2 and group A streptococcus, respectively). The main symptoms of both diseases are fever and cardiac involvement. Current therapy for PIMS-TS is based on anti-inflammatory treatment intravenous immunoglobulin (first-line), intravenous glucocorticoids (second-line), or biological therapy (third-line; including interleukin [IL]-1 antagonists, IL-6 receptor blockers, and anti-tumour necrosis factor agents). Vaccination might be good prophylaxis, but the efficacy and safety of the vaccines against SARS-CoV-2 have not yet been established in children. Interesting insights may be gained by considering PIMS-TS in light of what is known of ARF due to their similar courses, but there are still many unanswered questions surrounding this disease and its pathogenesis.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Rheumatic Fever / Systemic Inflammatory Response Syndrome / SARS-CoV-2 / COVID-19 Type of study: Etiology study Topics: Long Covid / Vaccines Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22094488

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rheumatic Fever / Systemic Inflammatory Response Syndrome / SARS-CoV-2 / COVID-19 Type of study: Etiology study Topics: Long Covid / Vaccines Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22094488