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Prevalence and Course of IgA and IgG Antibodies against SARS-CoV-2 in Healthcare Workers during the First Wave of the COVID-19 Outbreak in Germany: Interim Results from an Ongoing Observational Cohort Study.
Reinwald, Mark; Deckert, Peter Markus; Ritter, Oliver; Andresen, Henrike; Schreyer, Andreas G; Weylandt, Karsten Henrich; Dammermann, Werner; Lüth, Stefan.
  • Reinwald M; Department of Hematology and Oncology, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany.
  • Deckert PM; Department of Hematology and Oncology, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany.
  • Ritter O; Department of Cardiology and Pneumology, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany.
  • Andresen H; Department of Cardiology and Pneumology, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany.
  • Schreyer AG; Department of Radiology, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany.
  • Weylandt KH; Department of Gastroenterology, Metabolism and Oncology, Brandenburg Medical School Theodor Fontane, 16816 Neuruppin, Germany.
  • Dammermann W; Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany.
  • Lüth S; Department of Gastroenterology, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany.
Healthcare (Basel) ; 9(5)2021 Apr 22.
Article in English | MEDLINE | ID: covidwho-1202061
Semantic information from SemMedBD (by NLM)
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ABSTRACT
(1)

Background:

Healthcare workers (HCWs) are prone to intensified exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the ongoing pandemic. We prospectively analyzed the prevalence of antibodies against SARS-CoV-2 in HCWs at baseline and follow up with regard to clinical signs and symptoms in two university hospitals in Brandenburg, Germany. (2)

Methods:

Screening for anti-SARS-CoV-2 IgA and IgG antibodies was offered to HCWs at baseline and follow up two months thereafter in two hospitals of Brandenburg Medical School during the first wave of the COVID-19 pandemic in Germany in an ongoing observational cohort study. Medical history and signs and symptoms were recorded by questionnaires and analyzed. (3)

Results:

Baseline seroprevalence of anti-SARS-CoV-2 IgA was 11.7% and increased to 15% at follow up, whereas IgG seropositivity was 2.1% at baseline and 2.2% at follow up. The rate of asymptomatic seropositive cases was 39.5%. Symptoms were not associated with general seropositivity for anti-SARS-CoV-2; however, class switch from IgA to IgG was associated with increased symptom burden. (4)

Conclusions:

The seroprevalence of antibodies against SARS-CoV-2 was low in HCWs but higher compared to population data and increased over time. Screening for antibodies detected a significant proportion of seropositive participants cases without symptoms.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Healthcare9050498

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Healthcare9050498