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Temporal patterns of nasal symptoms in patients with mild severity SARS-CoV-2 infection.
Raad, Richard A; Ganti, Ashwin; Goshtasbi, Khodayar; Lehrich, Brandon M; Papagiannopoulos, Peter; LoSavio, Phillip; Mahdavinia, Mahboobeh; Kuan, Edward C; Batra, Pete S; Tajudeen, Bobby A.
  • Raad RA; Department of Otorhinolaryngology - Head & Neck Surgery, Rush University Medical Center, Chicago, IL, United States of America.
  • Ganti A; Department of Otolaryngology - Head and Neck Surgery, University of Minnesota, Minneapolis, MN, United States of America.
  • Goshtasbi K; Department of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, CA, United States of America.
  • Lehrich BM; Department of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, CA, United States of America.
  • Papagiannopoulos P; Department of Otorhinolaryngology - Head & Neck Surgery, Rush University Medical Center, Chicago, IL, United States of America.
  • LoSavio P; Department of Otorhinolaryngology - Head & Neck Surgery, Rush University Medical Center, Chicago, IL, United States of America.
  • Mahdavinia M; Division of Allergy/Immunology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States of America.
  • Kuan EC; Department of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, CA, United States of America.
  • Batra PS; Department of Otorhinolaryngology - Head & Neck Surgery, Rush University Medical Center, Chicago, IL, United States of America.
  • Tajudeen BA; Department of Otorhinolaryngology - Head & Neck Surgery, Rush University Medical Center, Chicago, IL, United States of America. Electronic address: Bobby_Tajudeen@rush.edu.
Am J Otolaryngol ; 42(6): 103076, 2021.
Article in English | MEDLINE | ID: covidwho-1202315
ABSTRACT

BACKGROUND:

No study to date has analyzed the progression of sinonasal symptoms over time in COVID-19 patients. The purpose of this study is to analyze the progression of sinonasal symptoms and risk factors for olfactory dysfunction in the mild severity COVID-19 patient.

METHODS:

An internet survey was used to assess sinonasal symptoms in patients with COVID-19. Changes in rhinologic domain and symptom-specific Sinonasal Outcome Test (SNOT-22) scores were compared at five time points two weeks before diagnosis, at diagnosis, two weeks after diagnosis, four weeks after diagnosis, and six months after diagnosis.

RESULTS:

521 responses were collected. Rhinologic domain SNOT-22 scores increased significantly (p < 0.001) to 8.94 at the time of diagnosis, remained elevated two weeks post-diagnosis (5.14, p = 0.004), and decreased significantly four weeks post-diagnosis (3.14, p = 0.004). Smell-specific SNOT-22 scores peaked at the time of diagnosis (2.05, p < 0.001), remained elevated two weeks after diagnosis (1.19, p < 0.001), and returned to baseline four weeks post-diagnosis (0.64, p > 0.999). Taste-specific SNOT-22 scores also peaked at diagnosis (2.06, p < 0.001), remained elevated two weeks after diagnosis (1.19, p < 0.001), and returned to baseline four weeks after diagnosis (0.71, p > 0.999). There were no significant differences in sense of smell or taste between 1-month and 6-month timepoints.

CONCLUSION:

Sinonasal symptoms, particularly loss of smell and taste, may be important presenting symptoms in the mild severity COVID-19 patient. Our findings support incorporating these symptoms into screening protocols. LEVEL OF EVIDENCE 4.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Paranasal Sinuses / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Am J Otolaryngol Year: 2021 Document Type: Article Affiliation country: J.amjoto.2021.103076

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Paranasal Sinuses / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Am J Otolaryngol Year: 2021 Document Type: Article Affiliation country: J.amjoto.2021.103076