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α1-Antitrypsin: Key Player or Bystander in Acute Respiratory Distress Syndrome?
Anesthesiology ; 134(5): 792-808, 2021 05 01.
Article in English | MEDLINE | ID: covidwho-1202432
Semantic information from SemMedBD (by NLM)
1. Hypoxemia COEXISTS_WITH Respiratory Distress Syndrom
Subject
Hypoxemia
Predicate
COEXISTS_WITH
Object
Respiratory Distress Syndrom
2. Pharmacotherapy TREATS Respiratory Distress Syndrom
Subject
Pharmacotherapy
Predicate
TREATS
Object
Respiratory Distress Syndrom
3. alpha 1-antitrypsin|ADRA1D PART_OF Serine Endopeptidases
Subject
alpha 1-antitrypsin|ADRA1D
Predicate
PART_OF
Object
Serine Endopeptidases
4. Protease Inhibitors INTERACTS_WITH Leukocyte Elastase
Subject
Protease Inhibitors
Predicate
INTERACTS_WITH
Object
Leukocyte Elastase
5. alpha 1-antitrypsin|ADRA1D AFFECTS Inflammation
Subject
alpha 1-antitrypsin|ADRA1D
Predicate
AFFECTS
Object
Inflammation
6. alpha 1-antitrypsin|ADRA1D TREATS Respiratory Distress Syndrom
Subject
alpha 1-antitrypsin|ADRA1D
Predicate
TREATS
Object
Respiratory Distress Syndrom
7. Hypoxemia COEXISTS_WITH Respiratory Distress Syndrome, Adult
Subject
Hypoxemia
Predicate
COEXISTS_WITH
Object
Respiratory Distress Syndrome, Adult
8. Pharmacotherapy TREATS Respiratory Distress Syndrome, Adult
Subject
Pharmacotherapy
Predicate
TREATS
Object
Respiratory Distress Syndrome, Adult
9. alpha 1-antitrypsin|ADRA1D PART_OF Serine Endopeptidases
Subject
alpha 1-antitrypsin|ADRA1D
Predicate
PART_OF
Object
Serine Endopeptidases
10. Protease Inhibitors INTERACTS_WITH Leukocyte Elastase
Subject
Protease Inhibitors
Predicate
INTERACTS_WITH
Object
Leukocyte Elastase
11. alpha 1-antitrypsin|ADRA1D AFFECTS Inflammation
Subject
alpha 1-antitrypsin|ADRA1D
Predicate
AFFECTS
Object
Inflammation
12. alpha 1-antitrypsin|ADRA1D TREATS Respiratory Distress Syndrome, Adult
Subject
alpha 1-antitrypsin|ADRA1D
Predicate
TREATS
Object
Respiratory Distress Syndrome, Adult
ABSTRACT
Acute respiratory distress syndrome is characterized by hypoxemia, altered alveolar-capillary permeability, and neutrophil-dominated inflammatory pulmonary edema. Despite decades of research, an effective drug therapy for acute respiratory distress syndrome remains elusive. The ideal pharmacotherapy for acute respiratory distress syndrome should demonstrate antiprotease activity and target injurious inflammatory pathways while maintaining host defense against infection. Furthermore, a drug with a reputable safety profile, low possibility of off-target effects, and well-known pharmacokinetics would be desirable. The endogenous 52-kd serine protease α1-antitrypsin has the potential to be a novel treatment option for acute respiratory distress syndrome. The main function of α1-antitrypsin is as an antiprotease, targeting neutrophil elastase in particular. However, studies have also highlighted the role of α1-antitrypsin in the modulation of inflammation and bacterial clearance. In light of the current SARS-CoV-2 pandemic, the identification of a treatment for acute respiratory distress syndrome is even more pertinent, and α1-antitrypsin has been implicated in the inflammatory response to SARS-CoV-2 infection.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Alpha 1-Antitrypsin / Proteinase Inhibitory Proteins, Secretory / Neutrophils Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Anesthesiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Alpha 1-Antitrypsin / Proteinase Inhibitory Proteins, Secretory / Neutrophils Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Anesthesiology Year: 2021 Document Type: Article