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[Low dose radiotherapy for COVID-19 pneumopathy: Biological rationale and literature review]. / Radiothérapie de faible dose pour la pneumopathie covid-19 : rationnel biologique et revue de la littérature.
Miran, C; Bonnet, É; Allignet, B; Clippe, S; El Hedi Zouai, M; Bosset, M; Fleury, B; Guy, J-B.
  • Miran C; Centre de radiothérapie Marie-Curie, 159, boulevard Maréchal-Juin, 26000 Valence, France; Hospices civils de Lyon, 69000 Lyon, France.
  • Bonnet É; Centre de radiothérapie Marie-Curie, 159, boulevard Maréchal-Juin, 26000 Valence, France.
  • Allignet B; Hospices civils de Lyon, 69000 Lyon, France.
  • Clippe S; Centre de radiothérapie Marie-Curie, 159, boulevard Maréchal-Juin, 26000 Valence, France.
  • El Hedi Zouai M; Centre de radiothérapie Marie-Curie, 159, boulevard Maréchal-Juin, 26000 Valence, France.
  • Bosset M; Centre de radiothérapie Marie-Curie, 159, boulevard Maréchal-Juin, 26000 Valence, France.
  • Fleury B; Centre de radiothérapie Marie-Curie, 159, boulevard Maréchal-Juin, 26000 Valence, France.
  • Guy JB; Centre de radiothérapie Marie-Curie, 159, boulevard Maréchal-Juin, 26000 Valence, France. Electronic address: dr.guy@cmc-valence.org.
Cancer Radiother ; 25(5): 494-501, 2021 Jul.
Article in French | MEDLINE | ID: covidwho-1202974
ABSTRACT
The world has now been facing the coronavirus disease 2019 (COVID-19) pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since over a year. If most of clinical presentations are benign, fragile patients are at greater risk of developing severe or fatal lung disease. Many therapies have been explored with very low impact on mortality. In this context, Kirkby et Mackenzie have published in April 2020 a report reminding the anti-inflammatory properties of low-dose radiotherapy (delivering less than 1Gy) and its use in the treatment of viral and bacterial pneumopathies before antibiotics era. Large in vivo and in vitro data have demonstrated the biological rationale and anti-inflammatory activity of low-dose radiotherapy in many pathologies. Over the past year, three phase I/II clinical trials have been published, as well as one randomized controlled trial, reporting the feasibility and the clinical and biological improvement of a 0.5 to 1Gy treatment dose to the entire lung. 13 other studies, including a randomized phase III trial, are currently ongoing worldwide. These studies may provide data in the effect of low-dose radiotherapy in the treatment of SARS-CoV-2 pneumonia. This article explains biological rationale of low-dose radiotherapy, and reports already published or ongoing studies on low-dose radiotherapy for SARS-CoV-2 pneumonia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: French Journal: Cancer Radiother Journal subject: Neoplasms / Radiotherapy Year: 2021 Document Type: Article Affiliation country: J.canrad.2021.03.005

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: French Journal: Cancer Radiother Journal subject: Neoplasms / Radiotherapy Year: 2021 Document Type: Article Affiliation country: J.canrad.2021.03.005