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Future considerations for the mRNA-lipid nanoparticle vaccine platform.
Igyártó, Botond Z; Jacobsen, Sonya; Ndeupen, Sonia.
  • Igyártó BZ; Thomas Jefferson University, Department of Microbiology and Immunology, 233 South 10th Street, Philadelphia, PA 19107, United States. Electronic address: botond.igyarto@jefferson.edu.
  • Jacobsen S; Thomas Jefferson University, Department of Microbiology and Immunology, 233 South 10th Street, Philadelphia, PA 19107, United States.
  • Ndeupen S; Thomas Jefferson University, Department of Microbiology and Immunology, 233 South 10th Street, Philadelphia, PA 19107, United States.
Curr Opin Virol ; 48: 65-72, 2021 06.
Article in English | MEDLINE | ID: covidwho-1203009
ABSTRACT
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) pioneered by Katalin Karikó and Drew Weissman at the University of Pennsylvania are a promising new vaccine platform used by two of the leading vaccines against coronavirus disease in 2019 (COVID-19). However, there are many questions regarding their mechanism of action in humans that remain unanswered. Here we consider the immunological features of LNP components and off-target effects of the mRNA, both of which could increase the risk of side effects. We suggest ways to mitigate these potential risks by harnessing dendritic cell (DC) biology.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dendritic Cells / RNA, Messenger / Vaccines / Immunization / Nanoparticles / Lipids Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Curr Opin Virol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dendritic Cells / RNA, Messenger / Vaccines / Immunization / Nanoparticles / Lipids Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Curr Opin Virol Year: 2021 Document Type: Article