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Adherence to subcutaneous immunotherapy with aeroallergens in real-life practice during the COVID-19 pandemic.
Yegit, Osman Ozan; Demir, Semra; Ünal, Derya; Olgaç, Müge; Terzioglu, Kadriye; Eyice Karabacak, Deniz; Tüzer, Can; Ayhan, Vehbi; Çolakoglu, Bahattin; Büyüköztürk, Suna; Gelincik, Asli.
  • Yegit OO; Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Demir S; Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Ünal D; Adult Immunology and Allergy Clinic, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey.
  • Olgaç M; Adult Immunology and Allergy Clinic, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.
  • Terzioglu K; Adult Immunology and Allergy Clinic, Kartal Dr Lütfi Kirdar Education and Research Hospital, Istanbul, Turkey.
  • Eyice Karabacak D; Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Tüzer C; Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Ayhan V; Adult Immunology and Allergy Clinic, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey.
  • Çolakoglu B; Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Büyüköztürk S; Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Gelincik A; Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Allergy ; 77(1): 197-206, 2022 01.
Article in English | MEDLINE | ID: covidwho-1203825
ABSTRACT

BACKGROUND:

The success of subcutaneous immunotherapy (SCIT) mostly depends on regular injections. Our aim was to investigate adherence to SCIT with aeroallergens during the COVID-19 pandemic and demonstrate clinical consequences of treatment disruptions in real life.

METHODS:

Visual analogue scale for quality of life (VAS-QoL), VAS for symptom scores (VAS-symptom), medication scores (MSs), and total symptom scores (TSS-6) were recorded during the pandemic in 327 adult allergic rhinitis and/or asthmatic patients receiving maintenance SCIT, and these scores were compared with the pre-pandemic data. Patients were grouped according to SCIT administration intervals; no delay (Group 1), <2 months (Group 2), and ≥2-month intervals (Group 3).

RESULTS:

A total of 104 (31.8%) patients (Group 3) were considered as nonadherent which was mostly related to receiving SCIT with HDMs and using public transportation for reaching the hospital. Median MS, VAS-symptom, and TSS-6 scores of Group 3 patients during the pandemic were higher than the pre-pandemic scores (p = 0.005, p < 0.001, p < 0.001, respectively), whereas median VAS-QoL scores of Group 3 during the pandemic were lower than the pre-pandemic scores (p < 0.001). Median TSS-6 and VAS-symptom scores were the highest in Group 3 compared with other groups (p < 0.001 for each comparison). Median VAS-QoL scores were the lowest in Group 3 compared with Group 1 and Group 2 (p < 0.001, p = 0.043, respectively).

CONCLUSION:

When precautions in allergy clinics are carefully applied, adherence to SCIT can be high during a pandemic. Patients must be encouraged to regularly adhere to SCIT injections since delays in SCIT administration can deteriorate clinical symptoms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rhinitis, Allergic / COVID-19 Type of study: Randomized controlled trials Limits: Adult / Humans Language: English Journal: Allergy Year: 2022 Document Type: Article Affiliation country: All.14876

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rhinitis, Allergic / COVID-19 Type of study: Randomized controlled trials Limits: Adult / Humans Language: English Journal: Allergy Year: 2022 Document Type: Article Affiliation country: All.14876