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Medium-term effects of COVID-19 pandemic on epilepsy: A follow-up study.
Lallana, Sofía; Fonseca, Elena; Restrepo, Juan Luis; Quintana, Manuel; Seijo-Raposo, Iván; Abraira, Laura; Santamarina, Estevo; Álvarez-Sabín, José; Toledo, Manuel.
  • Lallana S; Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Fonseca E; Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Restrepo JL; Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Quintana M; Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Seijo-Raposo I; Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Abraira L; Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Santamarina E; Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Álvarez-Sabín J; Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Toledo M; Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Acta Neurol Scand ; 144(1): 99-108, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1203828
Semantic information from SemMedBD (by NLM)
1. COVID-19 AFFECTS Epilepsy
Subject
COVID-19
Predicate
AFFECTS
Object
Epilepsy
2. Epilepsy PROCESS_OF Patients
Subject
Epilepsy
Predicate
PROCESS_OF
Object
Patients
3. COVID-19 AFFECTS Patients
Subject
COVID-19
Predicate
AFFECTS
Object
Patients
4. IMPACT gene AFFECTS Seizures
Subject
IMPACT gene
Predicate
AFFECTS
Object
Seizures
5. COVID-19 AFFECTS Cohort
Subject
COVID-19
Predicate
AFFECTS
Object
Cohort
6. Drug Resistant Epilepsy PREDISPOSES Fit frequency
Subject
Drug Resistant Epilepsy
Predicate
PREDISPOSES
Object
Fit frequency
7. COVID-19 AFFECTS Epilepsy
Subject
COVID-19
Predicate
AFFECTS
Object
Epilepsy
8. Epilepsy PROCESS_OF Patients
Subject
Epilepsy
Predicate
PROCESS_OF
Object
Patients
9. COVID-19 AFFECTS Patients
Subject
COVID-19
Predicate
AFFECTS
Object
Patients
10. IMPACT gene AFFECTS Seizures
Subject
IMPACT gene
Predicate
AFFECTS
Object
Seizures
11. COVID-19 AFFECTS Cohort
Subject
COVID-19
Predicate
AFFECTS
Object
Cohort
12. Drug Resistant Epilepsy PREDISPOSES Fit frequency
Subject
Drug Resistant Epilepsy
Predicate
PREDISPOSES
Object
Fit frequency
ABSTRACT

OBJECTIVE:

To analyze the medium-term impact of the COVID-19 pandemic on epilepsy patients, focusing on psychological effects and seizure control.

METHODS:

Prospective follow-up study to evaluate the medium-term effects of the COVID-19 pandemic on a cohort of epilepsy patients from a tertiary hospital previously surveyed during the first peak of the pandemic. Between July 1, 2020, and August 30, 2020, the patients answered an online 19-item questionnaire, HADS, and PSIQ scales. Short- and medium-term effects of the pandemic confinement and the perception of telemedicine were compared.

RESULTS:

153 patients completed the questionnaire, mean ± SD age, 47.6 ± 19.3 years; 49.7% women. Depression was reported by 43 patients, significantly more prevalent than in the short-term analysis (29.2% vs. 19.7%; p = .038). Anxiety (38.1% vs. 36.1%; p = 0.749) and insomnia (28.9% vs. 30.9%, p = .761) remained highly prevalent. Seventeen patients reported an increase in seizure frequency (11.1% vs. 9.1%, p = .515). The three factors independently associated with an increase in seizure frequency in the medium term were drug-resistant epilepsy (odds ratio [OR] = 8.2, 95% CI 2.06-32.52), depression (OR = 6.46, 95% CI 1.80-23.11), and a reduction in income (OR = 5.47, 95% CI 1.51-19.88). A higher proportion of patients found telemedicine unsatisfactory (11.2% vs. 2.4%), and a lower percentage (44.8% vs. 56.8%) found it very satisfactory (p = .005).

CONCLUSIONS:

Depression rates increased significantly after the first wave. Depression, drug-resistant epilepsy, and a reduction in family income were independent risk factors for an increased seizure frequency. Perception of telemedicine worsened, indicating need for re-adaptation.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Depression / Epilepsy / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Acta Neurol Scand Year: 2021 Document Type: Article Affiliation country: Ane.13439

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Depression / Epilepsy / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Acta Neurol Scand Year: 2021 Document Type: Article Affiliation country: Ane.13439