Your browser doesn't support javascript.
A Comparison of Less Invasive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Diagnostic Specimens in Nursing Home Residents-Arkansas, June-August 2020.
Gable, Paige; Huang, Jennifer Y; Gilbert, Sarah E; Bollinger, Susan; Lyons, Amanda K; Sabour, Sarah; Surie, Diya; Biedron, Caitlin; Haney, Tafarra; Beshearse, Elizabeth; Gregory, Christopher J; Seely, Kathryn A; Clemmons, Nakia S; Patil, Naveen; Kothari, Atul; Gulley, Trent; Garner, Kelley; Anderson, Karen; Thornburg, Natalie J; Halpin, Alison L; McDonald, L Clifford; Kutty, Preeta K; Brown, Allison C.
  • Gable P; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Huang JY; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Gilbert SE; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Bollinger S; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Lyons AK; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Sabour S; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Surie D; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Biedron C; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Haney T; Arkansas Department of Health, Little Rock, Arkansas, USA.
  • Beshearse E; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Gregory CJ; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Seely KA; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Clemmons NS; Arkansas Department of Health, Little Rock, Arkansas, USA.
  • Patil N; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Kothari A; Arkansas Department of Health, Little Rock, Arkansas, USA.
  • Gulley T; Arkansas Department of Health, Little Rock, Arkansas, USA.
  • Garner K; Arkansas Department of Health, Little Rock, Arkansas, USA.
  • Anderson K; Arkansas Department of Health, Little Rock, Arkansas, USA.
  • Thornburg NJ; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Halpin AL; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • McDonald LC; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Kutty PK; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Brown AC; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Clin Infect Dis ; 73(Suppl 1): S58-S64, 2021 07 15.
Article in English | MEDLINE | ID: covidwho-1205577
Semantic information from SemMedBD (by NLM)
1. Infected PROCESS_OF nursing home resident
Subject
Infected
Predicate
PROCESS_OF
Object
nursing home resident
2. 2019 novel coronavirus PROCESS_OF nursing home resident
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
nursing home resident
3. Infected PROCESS_OF nursing home resident
Subject
Infected
Predicate
PROCESS_OF
Object
nursing home resident
4. 2019 novel coronavirus PROCESS_OF nursing home resident
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
nursing home resident
ABSTRACT

BACKGROUND:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing remains essential for early identification and clinical management of cases. We compared the diagnostic performance of 3 specimen types for characterizing SARS-CoV-2 in infected nursing home residents.

METHODS:

A convenience sample of 17 residents were enrolled within 15 days of first positive SARS-CoV-2 result by real-time reverse transcription polymerase chain reaction (RT-PCR) and prospectively followed for 42 days. Anterior nasal swabs (AN), oropharyngeal swabs (OP), and saliva specimens (SA) were collected on the day of enrollment, every 3 days for the first 21 days, and then weekly for 21 days. Specimens were tested for presence of SARS-CoV-2 RNA using RT-PCR and replication-competent virus by viral culture.

RESULTS:

Comparing the 3 specimen types collected from each participant at each time point, the concordance of paired RT-PCR results ranged from 80% to 88%. After the first positive result, SA and OP were RT-PCR-positive for ≤48 days; AN were RT-PCR-positive for ≤33 days. AN had the highest percentage of RT-PCR-positive results (21/26 [81%]) when collected ≤10 days of participants' first positive result. Eleven specimens were positive by viral culture 9 AN collected ≤19 days following first positive result and 2 OP collected ≤5 days following first positive result.

CONCLUSIONS:

AN, OP, and SA were effective methods for repeated testing in this population. More AN than OP were positive by viral culture. SA and OP remained RT-PCR-positive longer than AN, which could lead to unnecessary interventions if RT-PCR detection occurred after viral shedding has likely ceased.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid