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Late Conditions Diagnosed 1-4 Months Following an Initial Coronavirus Disease 2019 (COVID-19) Encounter: A Matched-Cohort Study Using Inpatient and Outpatient Administrative Data-United States, 1 March-30 June 2020.
Chevinsky, Jennifer R; Tao, Guoyu; Lavery, Amy M; Kukielka, Esther A; Click, Eleanor S; Malec, Donald; Kompaniyets, Lyudmyla; Bruce, Beau B; Yusuf, Hussain; Goodman, Alyson B; Dixon, Meredith G; Nakao, Jolene H; Datta, S Deblina; MacKenzie, William R; Kadri, Sameer S; Saydah, Sharon; Giovanni, Jennifer E; Gundlapalli, Adi V.
  • Chevinsky JR; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Tao G; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Lavery AM; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Kukielka EA; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Click ES; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Malec D; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Kompaniyets L; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Bruce BB; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Yusuf H; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Goodman AB; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Dixon MG; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Nakao JH; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Datta SD; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • MacKenzie WR; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Kadri SS; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Saydah S; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Giovanni JE; Clinical Epidemiology Section, Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
  • Gundlapalli AV; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Clin Infect Dis ; 73(Suppl 1): S5-S16, 2021 07 15.
Article in English | MEDLINE | ID: covidwho-1364773
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF inpatient
Subject
COVID-19
Predicate
PROCESS_OF
Object
inpatient
2. COVID-19 PROCESS_OF Outpatients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Outpatients
3. Acute pulmonary embolism PROCESS_OF Adult
Subject
Acute pulmonary embolism
Predicate
PROCESS_OF
Object
Adult
4. COVID-19 PROCESS_OF Adult
Subject
COVID-19
Predicate
PROCESS_OF
Object
Adult
5. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
6. COVID-19 PROCESS_OF inpatient
Subject
COVID-19
Predicate
PROCESS_OF
Object
inpatient
7. COVID-19 PROCESS_OF Outpatients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Outpatients
8. Acute pulmonary embolism PROCESS_OF Adult
Subject
Acute pulmonary embolism
Predicate
PROCESS_OF
Object
Adult
9. COVID-19 PROCESS_OF Adult
Subject
COVID-19
Predicate
PROCESS_OF
Object
Adult
10. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
ABSTRACT

BACKGROUND:

Late sequelae of COVID-19 have been reported; however, few studies have investigated the time course or incidence of late new COVID-19-related health conditions (post-COVID conditions) after COVID-19 diagnosis. Studies distinguishing post-COVID conditions from late conditions caused by other etiologies are lacking. Using data from a large administrative all-payer database, we assessed type, association, and timing of post-COVID conditions following COVID-19 diagnosis.

METHODS:

Using the Premier Healthcare Database Special COVID-19 Release (release date, 20 October 2020) data, during March-June 2020, 27 589 inpatients and 46 857 outpatients diagnosed with COVID-19 (case-patients) were 11 matched with patients without COVID-19 through the 4-month follow-up period (control-patients) by using propensity score matching. In this matched-cohort study, adjusted ORs were calculated to assess for late conditions that were more common in case-patients than control-patients. Incidence proportion was calculated for conditions that were more common in case-patients than control-patients during 31-120 days following a COVID-19 encounter.

RESULTS:

During 31-120 days after an initial COVID-19 inpatient hospitalization, 7.0% of adults experienced ≥1 of 5 post-COVID conditions. Among adult outpatients with COVID-19, 7.7% experienced ≥1 of 10 post-COVID conditions. During 31-60 days after an initial outpatient encounter, adults with COVID-19 were 2.8 times as likely to experience acute pulmonary embolism as outpatient control-patients and also more likely to experience a range of conditions affecting multiple body systems (eg, nonspecific chest pain, fatigue, headache, and respiratory, nervous, circulatory, and gastrointestinal symptoms) than outpatient control-patients.

CONCLUSIONS:

These findings add to the evidence of late health conditions possibly related to COVID-19 in adults following COVID-19 diagnosis and can inform healthcare practice and resource planning for follow-up COVID-19 care.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Outpatients / COVID-19 Type of study: Cohort study / Diagnostic study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Outpatients / COVID-19 Type of study: Cohort study / Diagnostic study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid