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Seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of New York City metro blood donors using multiple SARS-CoV-2 serological assays: Implications for controlling the epidemic and "Reopening".
Jin, Daniel K; Nesbitt, Daniel J; Yang, Jenny; Chen, Haidee; Horowitz, Julie; Jones, Marcus; Vandergaast, Rianna; Carey, Timothy; Reiter, Samantha; Russell, Stephen J; Kyratsous, Christos; Hooper, Andrea; Hamilton, Jennifer; Ferreira, Manuel; Deng, Sarah; Straus, Donna; Baras, Aris; Hillyer, Christopher D; Luchsinger, Larry L.
  • Jin DK; Laboratory of Stem Cell Regenerative Research, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States of America.
  • Nesbitt DJ; Laboratory of Stem Cell Regenerative Research, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States of America.
  • Yang J; Laboratory of Stem Cell Regenerative Research, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States of America.
  • Chen H; Laboratory of Stem Cell Regenerative Research, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States of America.
  • Horowitz J; Regeneron Genetics Center, Tarrytown, NY, United States of America.
  • Jones M; Regeneron Genetics Center, Tarrytown, NY, United States of America.
  • Vandergaast R; Imanis Life Sciences, Rochester, MN, United States of America.
  • Carey T; Imanis Life Sciences, Rochester, MN, United States of America.
  • Reiter S; Imanis Life Sciences, Rochester, MN, United States of America.
  • Russell SJ; Vyriad, Inc., Rochester, MN, United States of America.
  • Kyratsous C; Imanis Life Sciences, Rochester, MN, United States of America.
  • Hooper A; Mayo Clinic Department of Molecular Medicine, Rochester, MN, United States of America.
  • Hamilton J; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States of America.
  • Ferreira M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States of America.
  • Deng S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States of America.
  • Straus D; Regeneron Genetics Center, Tarrytown, NY, United States of America.
  • Baras A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States of America.
  • Hillyer CD; New York Blood Center Enterprises, New York, NY, United States of America.
  • Luchsinger LL; Regeneron Genetics Center, Tarrytown, NY, United States of America.
PLoS One ; 16(4): e0250319, 2021.
Article in English | MEDLINE | ID: covidwho-1833525
ABSTRACT
Projections of the stage of the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic and local, regional and national public health policies to limit coronavirus spread as well as "reopen" cities and states, are best informed by serum neutralizing antibody titers measured by reproducible, high throughput, and statically credible antibody (Ab) assays. To date, a myriad of Ab tests, both available and FDA authorized for emergency, has led to confusion rather than insight per se. The present study reports the results of a rapid, point-in-time 1,000-person cohort study using serial blood donors in the New York City metropolitan area (NYC) using multiple serological tests, including enzyme-linked immunosorbent assays (ELISAs) and high throughput serological assays (HTSAs). These were then tested and associated with assays for neutralizing Ab (NAb). Of the 1,000 NYC blood donor samples in late June and early July 2020, 12.1% and 10.9% were seropositive using the Ortho Total Ig and the Abbott IgG HTSA assays, respectively. These serological assays correlated with neutralization activity specific to SARS-CoV-2. The data reported herein suggest that seroconversion in this population occurred in approximately 1 in 8 blood donors from the beginning of the pandemic in NYC (considered March 1, 2020). These findings deviate with an earlier seroprevalence study in NYC showing 13.7% positivity. Collectively however, these data demonstrate that a low number of individuals have serologic evidence of infection during this "first wave" and suggest that the notion of "herd immunity" at rates of ~60% or higher are not near. Furthermore, the data presented herein show that the nature of the Ab-based immunity is not invariably associated with the development of NAb. While the blood donor population may not mimic precisely the NYC population as a whole, rapid assessment of seroprevalence in this cohort and serial reassessment could aid public health decision making.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0250319

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0250319