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The Genetic Variant of SARS-CoV-2: would It Matter for Controlling the Devastating Pandemic?
Guo, Shuxin; Liu, Kefang; Zheng, Jun.
  • Guo S; Faculty of Health Sciences, University of Macau, Macau SAR, China.
  • Liu K; Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China.
  • Zheng J; Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China.
Int J Biol Sci ; 17(6): 1476-1485, 2021.
Article in English | MEDLINE | ID: covidwho-1206431
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
2. Vaccines AUGMENTS Immune response
Subject
Vaccines
Predicate
AUGMENTS
Object
Immune response
3. Variation (Genetics) AFFECTS viral transmission
Subject
Variation (Genetics)
Predicate
AFFECTS
Object
viral transmission
4. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
5. Vaccines AUGMENTS Immune response
Subject
Vaccines
Predicate
AUGMENTS
Object
Immune response
6. Variation (Genetics) AFFECTS viral transmission
Subject
Variation (Genetics)
Predicate
AFFECTS
Object
viral transmission
ABSTRACT
The pandemic of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is far from being controlled despite the great effort that have been taken throughout the world. Herd immunity through vaccination is our major expectation to rein the virus. However, the emergence of widespread genetic variants could potentially undermine the vaccines. The evidence that some variants could evade immune responses elicited by vaccines and previous infection is growing. In this review, we summarized the current understanding on five notable genetic variants, i.e., D614G, Cluster 5, VOC 202012/01, 501Y.V2 and P.1, and discussed the potential impact of these variants on the virus transmission, pathogenesis and vaccine efficacy. We also highlight that mutations in the N-terminal domain of spike protein should be considered when evaluating the antibody neutralization abilities. Among these genetic variants, a concern of genetic variant 501Y.V2 to escape the protection by vaccines was raised. We therefore call for new vaccines targeting this variant to be developed.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Mutation Type of study: Experimental Studies / Observational study Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: Int J Biol Sci Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Ijbs.59137

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Mutation Type of study: Experimental Studies / Observational study Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: Int J Biol Sci Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Ijbs.59137