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Expert consensus on the monitoring of transthyretin amyloid cardiomyopathy.
Garcia-Pavia, Pablo; Bengel, Frank; Brito, Dulce; Damy, Thibaud; Duca, Franz; Dorbala, Sharmila; Nativi-Nicolau, Jose; Obici, Laura; Rapezzi, Claudio; Sekijima, Yoshiki; Elliott, Perry M.
  • Garcia-Pavia P; Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, CIBERCV, Madrid, Spain.
  • Bengel F; Universidad Francisco de Vitoria (UFV), Pozuelo de Alarcon, Spain.
  • Brito D; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart, Amsterdam, The Netherlands.
  • Damy T; Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
  • Duca F; Heart and Vessels Department, Centro Hospitalar Universitário de Lisboa Norte, CCUL, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
  • Dorbala S; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart, Amsterdam, The Netherlands.
  • Nativi-Nicolau J; Referral Center for Cardiac Amyloidosis, GRC Amyloid Research Institute, Department of Cardiology, Centre Hospitalier Universitaire Henri Mondor, DHU-ATVB Créteil, France and Inserm U955, Université Paris-Est Créteil (UPEC), Créteil, France.
  • Obici L; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
  • Rapezzi C; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
  • Sekijima Y; Department of Medicine, University of Utah Health Care, Salt Lake City, UT, USA.
  • Elliott PM; Amyloidosis Research and Treatment Centre, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
Eur J Heart Fail ; 23(6): 895-905, 2021 06.
Article in English | MEDLINE | ID: covidwho-1206759
Semantic information from SemMedBD (by NLM)
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ABSTRACT
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a life-threatening condition with a heterogeneous clinical presentation. The recent availability of treatment for ATTR-CM has stimulated increased awareness of the disease and patient identification. Stratification of patients with ATTR-CM is critical for optimal management and treatment; however, monitoring disease progression is challenging and currently lacks best-practice guidance. In this report, experts with experience in treating amyloidosis and ATTR-CM developed consensus recommendations for monitoring the course of patients with ATTR-CM and proposed meaningful thresholds and frequency for specific parameters. A set of 11 measurable features across three separate domains were evaluated (i) clinical and functional endpoints, (ii) biomarkers and laboratory markers, and (iii) imaging and electrocardiographic parameters. Experts recommended that one marker from each of the three domains provides the minimum requirements for assessing disease progression. Assessment of cardiac disease status should be part of a multiparametric evaluation in which progression, stability or improvement of other involved systems in transthyretin amyloidosis should also be considered. Additional data from placebo arms of clinical trials and future studies assessing ATTR-CM will help to elucidate, refine and define these and other measurements.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Amyloid Neuropathies, Familial / Heart Failure / Cardiomyopathies Type of study: Controlled clinical trial / Diagnostic study / Clinical Practice Guide / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Eur J Heart Fail Journal subject: Cardiology Year: 2021 Document Type: Article Affiliation country: Ejhf.2198

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Amyloid Neuropathies, Familial / Heart Failure / Cardiomyopathies Type of study: Controlled clinical trial / Diagnostic study / Clinical Practice Guide / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Eur J Heart Fail Journal subject: Cardiology Year: 2021 Document Type: Article Affiliation country: Ejhf.2198