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Changes in RT-PCR test results and symptoms during the menstrual cycle of female individuals infected with SARS-CoV-2: Report of two cases.
Zheng, Hua; Tan, Juan; Ma, Ke; Meng, Weihua.
  • Zheng H; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Tan J; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ma K; Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Meng W; Division of Population Health Sciences, School of Medicine, University of Dundee, Dundee, UK.
J Med Virol ; 93(1): 541-545, 2021 01.
Article in English | MEDLINE | ID: covidwho-1206793
ABSTRACT
The implications of the menstrual cycle for disease susceptibility, development, and severity of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are largely unknown. Here, we describe two women infected with SARS-CoV-2 whose real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test results and symptoms changed during the menstrual cycle. The first patient developed a fever on the first day of her menstrual period, and again on the first day of her next menstrual period after hospital discharge. RT-PCR test results were positive during the first menstrual period before admission, but turned negative during hospitalization, and then were positive again during the second menstrual period after hospital discharge. Another one also developed a fever again on the first day of her menstrual period after hospital discharge. RT-PCR test results were negative before admission and during hospitalization, but turned positive during the first menstrual period after hospital discharge. The cases indicate sex hormones may play an important role in SARS-CoV-2 infection. For women with history of exposure to SARS-CoV-2, the management protocol should include assessment of the menstrual status.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Menstrual Cycle Type of study: Case report / Diagnostic study / Prognostic study Limits: Adult / Female / Humans Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26275

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Menstrual Cycle Type of study: Case report / Diagnostic study / Prognostic study Limits: Adult / Female / Humans Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26275