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Characterization of T lymphocytes in severe COVID-19 patients.
Fenoglio, Daniela; Dentone, Chiara; Parodi, Alessia; Di Biagio, Antonio; Bozzano, Federica; Vena, Antonio; Fabbi, Marina; Ferrera, Francesca; Altosole, Tiziana; Bruzzone, Bianca; Giacomini, Mauro; Pelosi, Paolo; De Maria, Andrea; Bassetti, Matteo; De Palma, Raffaele; Filaci, Gilberto.
  • Fenoglio D; Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
  • Dentone C; Biotherapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Parodi A; Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Di Biagio A; Biotherapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Bozzano F; Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Vena A; Department of Health Sciences, University of Genoa, Genoa, Italy.
  • Fabbi M; Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Ferrera F; Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Altosole T; Biotherapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Bruzzone B; Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
  • Giacomini M; Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
  • Pelosi P; Hygiene Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • De Maria A; Department of Informatics Bioengineering, Robotics, and Systems Engineering (DIBRIS), University of Genoa, Genoa, Italy.
  • Bassetti M; Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
  • De Palma R; Anesthesia and Intensive Care Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Filaci G; Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
J Med Virol ; 93(9): 5608-5613, 2021 09.
Article in English | MEDLINE | ID: covidwho-1363674
ABSTRACT
In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.27037

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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.27037