Can molecular mimicry explain the cytokine storm of SARS-CoV-2?: An in silico approach.
J Med Virol
; 93(9): 5350-5357, 2021 Sep.
Article
in English
| MEDLINE | ID: covidwho-1384240
ABSTRACT
PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper-inflammatory state in SARS-CoV-2 patients.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Poly(ADP-ribose) Polymerases
/
Cytokine Release Syndrome
/
Coronavirus Papain-Like Proteases
/
SARS-CoV-2
/
COVID-19
/
Neoplasm Proteins
Language:
English
Journal:
J Med Virol
Year:
2021
Document Type:
Article
Affiliation country:
JMV.27040
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