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Decreased in-hospital mortality associated with aspirin administration in hospitalized patients due to severe COVID-19.
Haji Aghajani, Mohammad; Moradi, Omid; Amini, Hossein; Azhdari Tehrani, Hamed; Pourheidar, Elham; Rabiei, Mohammad M; Sistanizad, Mohammad.
  • Haji Aghajani M; Prevention of Cardiovascular Disease Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Moradi O; Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Amini H; Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Azhdari Tehrani H; Department of Hematology and Medical Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Pourheidar E; Department of Hematology and Medical Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Rabiei MM; Clinical Research Development Unit of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Sistanizad M; Prevention of Cardiovascular Disease Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Med Virol ; 93(9): 5390-5395, 2021 09.
Article in English | MEDLINE | ID: covidwho-1206845
Semantic information from SemMedBD (by NLM)
1. COVID-19 CAUSES Thrombosis
Subject
COVID-19
Predicate
CAUSES
Object
Thrombosis
2. COVID-19 CAUSES Thrombophilia
Subject
COVID-19
Predicate
CAUSES
Object
Thrombophilia
3. Comorbidity PROCESS_OF Patients
Subject
Comorbidity
Predicate
PROCESS_OF
Object
Patients
4. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
5. COVID-19 CAUSES Thrombosis
Subject
COVID-19
Predicate
CAUSES
Object
Thrombosis
6. COVID-19 CAUSES Thrombophilia
Subject
COVID-19
Predicate
CAUSES
Object
Thrombophilia
7. Comorbidity PROCESS_OF Patients
Subject
Comorbidity
Predicate
PROCESS_OF
Object
Patients
8. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
ABSTRACT
Hypercoagulability and thrombosis caused by coronavirus disease 2019 (COVID-19) are related to the higher mortality rate. Because of limited data on the antiplatelet effect, we aimed to evaluate the impact of aspirin add-on therapy on the outcome of the patients hospitalized due to severe COVID-19. In this cohort study, patients with a confirmed diagnosis of severe COVID-19 admitted to Imam Hossein Medical Center, Tehran, Iran from March 2019 to July 2020 were included. Demographics and related clinical data during their hospitalization were recorded. The mortality rate of the patients was considered as the primary outcome and its association with aspirin use was assessed. Nine hundred and ninety-one patients were included, of that 336 patients (34%) received aspirin during their hospitalization and 655 ones (66%) did not. Comorbidities were more prevalent in the patients who were receiving aspirin. Results from the multivariate COX proportional model demonstrated a significant independent association between aspirin use and reduction in the risk of in-hospital mortality (0.746 [0.560-0.994], p = 0.046). Aspirin use in hospitalized patients with COVID-19 is associated with a significant decrease in mortality rate. Further prospective randomized controlled trials are needed to assess the efficacy and adverse effects of aspirin administration in this population.
Subject(s)
Aspirin/therapeutic use; COVID-19/drug therapy; Disseminated Intravascular Coagulation/drug therapy; Platelet Aggregation Inhibitors/therapeutic use; Pulmonary Embolism/drug therapy; SARS-CoV-2/pathogenicity; Adenosine Monophosphate/analogs & derivatives; Adenosine Monophosphate/therapeutic use; Adult; Aged; Alanine/analogs & derivatives; Alanine/therapeutic use; Antiviral Agents/therapeutic use; Blood Platelets/drug effects; Blood Platelets/pathology; Blood Platelets/virology; COVID-19/complications; COVID-19/mortality; COVID-19/virology; Coronary Artery Disease/complications; Coronary Artery Disease/drug therapy; Coronary Artery Disease/mortality; Coronary Artery Disease/virology; Diabetes Mellitus/drug therapy; Diabetes Mellitus/mortality; Diabetes Mellitus/virology; Disseminated Intravascular Coagulation/complications; Disseminated Intravascular Coagulation/mortality; Disseminated Intravascular Coagulation/virology; Drug Combinations; Female; Hospital Mortality; Humans; Hypertension/complications; Hypertension/drug therapy; Hypertension/mortality; Hypertension/virology; Iran; Lopinavir/therapeutic use; Lung/blood supply; Lung/drug effects; Lung/pathology; Lung/virology; Male; Middle Aged; Pulmonary Embolism/complications; Pulmonary Embolism/mortality; Pulmonary Embolism/virology; Respiration, Artificial/mortality; Respiration, Artificial/statistics & numerical data; Retrospective Studies; Ritonavir/therapeutic use; SARS-CoV-2/drug effects; Severity of Illness Index; Survival Analysis; Treatment Outcome
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / Platelet Aggregation Inhibitors / Aspirin / Disseminated Intravascular Coagulation / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Observational study / Randomized controlled trials / Risk factors Topics: Long Covid Country/Region as subject: Asia Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.27053

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / Platelet Aggregation Inhibitors / Aspirin / Disseminated Intravascular Coagulation / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Observational study / Randomized controlled trials / Risk factors Topics: Long Covid Country/Region as subject: Asia Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.27053