Your browser doesn't support javascript.
Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.
Reilev, Mette; Kristensen, Kasper Bruun; Pottegård, Anton; Lund, Lars Christian; Hallas, Jesper; Ernst, Martin Thomsen; Christiansen, Christian Fynbo; Sørensen, Henrik Toft; Johansen, Nanna Borup; Brun, Nikolai Constantin; Voldstedlund, Marianne; Støvring, Henrik; Thomsen, Marianne Kragh; Christensen, Steffen; Gubbels, Sophie; Krause, Tyra Grove; Mølbak, Kåre; Thomsen, Reimar Wernich.
  • Reilev M; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Kristensen KB; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Pottegård A; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Lund LC; Hospital Pharmacy Funen, Odense University Hospital, Odense, Denmark.
  • Hallas J; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Ernst MT; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Christiansen CF; Department of Clinical Biochemistry and Clinical Pharmacology, Odense University Hospital, Odense, Denmark.
  • Sørensen HT; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Johansen NB; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
  • Brun NC; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
  • Voldstedlund M; Center for Population Health and Sciences, Stanford University, Stanford, CA, USA.
  • Støvring H; Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.
  • Thomsen MK; Department of Medical Evaluation and Biostatistics, Danish Medicines Agency, Copenhagen, Denmark.
  • Christensen S; Statens Serum Institut, Copenhagen, Denmark.
  • Gubbels S; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Krause TG; Department of Public Health-Biostatistics, Aarhus University, Aarhus, Denmark.
  • Mølbak K; Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.
  • Thomsen RW; Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark.
Int J Epidemiol ; 49(5): 1468-1481, 2020 10 01.
Article in English | MEDLINE | ID: covidwho-1207290
ABSTRACT

BACKGROUND:

Population-level knowledge on individuals at high risk of severe and fatal coronavirus disease 2019 (COVID-19) is urgently needed to inform targeted protection strategies in the general population.

METHODS:

We examined characteristics and predictors of hospitalization and death in a nationwide cohort of all Danish individuals tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 27 February 2020 until 19 May 2020.

RESULTS:

We identified 11 122 SARS-CoV-2 polymerase chain reaction-positive cases of whom 80% were community-managed and 20% were hospitalized. Thirty-day all-cause mortality was 5.2%. Age was strongly associated with fatal disease {odds ratio [OR] 15 [95% confidence interval (CI) 9-26] for 70-79 years, increasing to OR 90 (95% CI 50-162) for ≥90 years, when compared with cases aged 50-59 years and adjusted for sex and number of co-morbidities}. Similarly, the number of co-morbidities was associated with fatal disease [OR 5.2 (95% CI 3.4-8.0), for cases with at least four co-morbidities vs no co-morbidities] and 79% of fatal cases had at least two co-morbidities. Most major chronic diseases were associated with hospitalization, with ORs ranging from 1.3-1.4 (e.g. stroke, ischaemic heart disease) to 2.6-3.4 (e.g. heart failure, hospital-diagnosed kidney disease, organ transplantation) and with mortality with ORs ranging from 1.1-1.3 (e.g. ischaemic heart disease, hypertension) to 2.5-3.2 (e.g. major psychiatric disorder, organ transplantation). In the absence of co-morbidities, mortality was <5% in persons aged ≤80 years.

CONCLUSIONS:

In this nationwide population-based COVID-19 study, increasing age and multimorbidity were strongly associated with hospitalization and death. In the absence of co-morbidities, the mortality was, however, <5% until the age of 80 years.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Nucleic Acid Testing / COVID-19 / Hospitalization Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Int J Epidemiol Year: 2020 Document Type: Article Affiliation country: Ije

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Nucleic Acid Testing / COVID-19 / Hospitalization Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Int J Epidemiol Year: 2020 Document Type: Article Affiliation country: Ije