Gastrointestinal Microenvironment and the Gut-Lung Axis in the Immune Responses of Severe COVID-19.
Front Mol Biosci
; 8: 647508, 2021.
Article
in English
| MEDLINE | ID: covidwho-1207702
ABSTRACT
The global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented threat to the human health. A close association of the digestive tract is implied by the high frequency of gastrointestinal syndromes among COVID-19 patients. A better understanding of the role of intestinal microenvironment in COVID-19 immunopathology will be helpful to improve the control of COVID-19 associated morbidity and mortality. This review summarizes the immune responses associated with the severity of COVID-19, the current evidence of SARS-CoV-2 intestinal tropism, and the potential involvement of gut microenvironment in COVID-19 severity. Additionally, we discuss the therapeutic potential of probiotics as an alternative medicine to prevent or alleviate severe COVID-19 outcome.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Prognostic study
Topics:
Traditional medicine
Language:
English
Journal:
Front Mol Biosci
Year:
2021
Document Type:
Article
Affiliation country:
Fmolb.2021.647508
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