The basic reproductive number and particle-to-plaque ratio: comparison of these two parameters of viral infectivity.

McCormick, Winston; Mermel, Leonard A

McCormick, Winston; Mermel, Leonard A.

McCormick W; Warren Alpert Medical School of Brown University, 222 Richmond St, Providence, RI, 02903, USA.
Mermel LA; Department of Medicine, Warren Alpert Medical School of Brown University, 222 Richmond St, Providence, RI, 02903, USA. lmermel@lifespan.org.

Virol J ; 18(1): 92, 2021 04 30.

Article in English | MEDLINE | ID: covidwho-1208522

ABSTRACT

ABSTRACT

The COVID-19 pandemic has brought more widespread attention to the basic reproductive number (Ro), an epidemiologic measurement. A lesser-known measure of virologic infectivity is the particle-to-plaque ratio (PPFU). We suggest that comparison between the two parameters may assist in better understanding viral transmission dynamics.

Subject(s)

COVID-19/epidemiology; SARS-CoV-2/pathogenicity; Virus Diseases/epidemiology; Basic Reproduction Number; Cells, Cultured; Humans

Keywords

Basic reproductive number; COVID-19; Particle-to-pfu; Particle-to-plaque; Viral transmission

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / SARS-CoV-2 / COVID-19 Type of study: Observational study Limits: Humans Language: English Journal: Virol J Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: S12985-021-01566-4

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