Your browser doesn't support javascript.
JAK inhibitors: Ten years after.
Spinelli, Francesca Romana; Meylan, Françoise; O'Shea, John J; Gadina, Massimo.
  • Spinelli FR; Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari-Reumatologia, Sapienza Università di Roma, Rome, Italy.
  • Meylan F; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Translational Immunology Section, Bethesda, MD, USA.
  • O'Shea JJ; Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Gadina M; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Translational Immunology Section, Bethesda, MD, USA.
Eur J Immunol ; 51(7): 1615-1627, 2021 07.
Article in English | MEDLINE | ID: covidwho-1209440
ABSTRACT
The European Journal of Immunology was launched 50 years ago, coinciding with the discovery of many cytokines and growth factors and the emergence of an entirely new field of research. Ultimately, our knowledge about the biological activity of these factors allowed us to better understand how the immune system functions in the context of inflammatory and autoimmune diseases leading to the development of targeted biologic therapies. The study of cytokine signal transduction led to the discovery of Janus kinases (JAK), and the consideration of therapeutically targeting JAKs to treat immune and inflammatory diseases. This year also marks the tenth anniversary of the approval of the first JAK inhibitor (jakinib) and now there are a total of nine approved jakinibs for treatment of rheumatologic, dermatologic, gastrointestinal, and neoplastic indications and most recently COVID-19. Here, we summarized the discoveries that led to development of first-generation jakinibs, discussed some of the newer, possibly more selective jakinibs, as well as jakinibs that also target other kinases. We also illustrated the rationale behind the application of these drugs in the treatment of COVID-19 cytokine storm. In this review, we will discuss the clinical success of jakinibs, the gaps in our understanding of their biological activities as well as challenges in regard to their clinical application.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Janus Kinase Inhibitors / Cytokine Release Syndrome / COVID-19 Drug Treatment / Hypersensitivity Type of study: Prognostic study Limits: Humans Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202048922

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Janus Kinase Inhibitors / Cytokine Release Syndrome / COVID-19 Drug Treatment / Hypersensitivity Type of study: Prognostic study Limits: Humans Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202048922