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Low serum albumin and the risk of hospitalization in COVID-19 infection: A retrospective case-control study.
Acharya, Roshan; Poudel, Dilli; Patel, Aakash; Schultz, Evan; Bourgeois, Michael; Paswan, Rishi; Stockholm, Scott; Batten, Macylen; Kafle, Smita; Atkinson, Amanda; Sarwar, Hafiz.
  • Acharya R; Department of Internal Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, United States of America.
  • Poudel D; Department of Rheumatology, Indiana Regional Medical Center, Indiana, PA, United States of America.
  • Patel A; Department of Internal Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, United States of America.
  • Schultz E; Department of Internal Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, United States of America.
  • Bourgeois M; Department of Internal Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, United States of America.
  • Paswan R; Department of Internal Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, United States of America.
  • Stockholm S; Department of Internal Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, United States of America.
  • Batten M; Department of Internal Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, United States of America.
  • Kafle S; RN-BSN Program, Fayetteville State University, Fayetteville, NC, United States of America.
  • Atkinson A; Department of Emergency Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, United States of America.
  • Sarwar H; Department of Critical Care Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, United States of America.
PLoS One ; 16(4): e0250906, 2021.
Article in English | MEDLINE | ID: covidwho-1209497
ABSTRACT

BACKGROUND:

The data on the COVID-19 patients who were discharged to self-quarantine is lacking.

AIM:

The aim of the study was to investigate the percentage of COVID-19 positive patients that were hospitalized within a three-week period after discharge from ED to self-quarantine.

METHODS:

The patients who had confirmed SARS-CoV-2 on RT-PCR of the nasopharyngeal swab and were discharged from ED of a tertiary care hospital in the USA to self-quarantine from March 01- July 31, 2020, were included. Patients were divided into two groups based on serum albumin levels and were followed up for three weeks to see if low level of albumin increased the risk of hospitalization. Univariate and multivariate logistic regression analyses were performed to study the effect of albumin level and outcomes.

RESULTS:

A total of 112 patients were included in the study out of which 65 had low serum albumin (<3.5 g/dL) and 47 had normal serum albumin (≥3.5 g/dL). More than 10% of patients discharged to self-quarantine needed hospitalization within three weeks. The Low albumin group had more co-morbidities at baseline. The low serum albumin group had 10 (15.38%) vs 2 (4.26%), p = 0.06 hospitalizations as compared to the normal serum albumin group. The multivariate logistic regression analysis did not reveal lower odds of hospitalization in the group with normal albumin, (OR 0.26, 95% CI 0.03-1.92, p = 0.19) after controlling for age, sex, and various co-morbidities.

CONCLUSION:

The low serum albumin was not associated with the risk of hospitalization in COVID-19 patients who were initially discharged to self-quarantine.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Serum Albumin, Human / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0250906

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serum Albumin, Human / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0250906