Your browser doesn't support javascript.
Lung Cancer and Heart Disease Risks Associated With Low-Dose Pulmonary Radiotherapy to COVID-19 Patients With Different Background Risks.
Shuryak, Igor; Kachnic, Lisa A; Brenner, David J.
  • Shuryak I; Center for Radiological Research, Department of Radiation Oncology; Department of Radiation Oncology, Columbia University Irving Medical Center, New York. Electronic address: is144@cumc.columbia.edu.
  • Kachnic LA; Department of Radiation Oncology, Columbia University Irving Medical Center, New York.
  • Brenner DJ; Center for Radiological Research, Department of Radiation Oncology; Department of Radiation Oncology, Columbia University Irving Medical Center, New York.
Int J Radiat Oncol Biol Phys ; 111(1): 233-239, 2021 09 01.
Article in English | MEDLINE | ID: covidwho-1209500
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Low Dose Radiation Therapy AFFECTS Malignant neoplasm of lung
Subject
Low Dose Radiation Therapy
Predicate
AFFECTS
Object
Malignant neoplasm of lung
3. Lung LOCATION_OF Symptom severe
Subject
Lung
Predicate
LOCATION_OF
Object
Symptom severe
4. Symptom severe PROCESS_OF Patients
Subject
Symptom severe
Predicate
PROCESS_OF
Object
Patients
5. Low Dose Radiation Therapy TREATS COVID-19
Subject
Low Dose Radiation Therapy
Predicate
TREATS
Object
COVID-19
6. Smoker PROCESS_OF Woman
Subject
Smoker
Predicate
PROCESS_OF
Object
Woman
7. High risk factors PROCESS_OF Patients
Subject
High risk factors
Predicate
PROCESS_OF
Object
Patients
8. Malignant neoplasm of lung PROCESS_OF Patients
Subject
Malignant neoplasm of lung
Predicate
PROCESS_OF
Object
Patients
9. cardiac event PROCESS_OF Patients
Subject
cardiac event
Predicate
PROCESS_OF
Object
Patients
10. Heart LOCATION_OF risk factors
Subject
Heart
Predicate
LOCATION_OF
Object
risk factors
11. risk factors PROCESS_OF Patients
Subject
risk factors
Predicate
PROCESS_OF
Object
Patients
12. Low Dose Radiation Therapy TREATS Symptom severe
Subject
Low Dose Radiation Therapy
Predicate
TREATS
Object
Symptom severe
13. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
14. Low Dose Radiation Therapy AFFECTS Malignant neoplasm of lung
Subject
Low Dose Radiation Therapy
Predicate
AFFECTS
Object
Malignant neoplasm of lung
15. Lung LOCATION_OF Symptom severe
Subject
Lung
Predicate
LOCATION_OF
Object
Symptom severe
16. Symptom severe PROCESS_OF Patients
Subject
Symptom severe
Predicate
PROCESS_OF
Object
Patients
17. Low Dose Radiation Therapy TREATS COVID-19
Subject
Low Dose Radiation Therapy
Predicate
TREATS
Object
COVID-19
18. Smoker PROCESS_OF Woman
Subject
Smoker
Predicate
PROCESS_OF
Object
Woman
19. High risk factors PROCESS_OF Patients
Subject
High risk factors
Predicate
PROCESS_OF
Object
Patients
20. Malignant neoplasm of lung PROCESS_OF Patients
Subject
Malignant neoplasm of lung
Predicate
PROCESS_OF
Object
Patients
21. cardiac event PROCESS_OF Patients
Subject
cardiac event
Predicate
PROCESS_OF
Object
Patients
22. Heart LOCATION_OF risk factors
Subject
Heart
Predicate
LOCATION_OF
Object
risk factors
23. risk factors PROCESS_OF Patients
Subject
risk factors
Predicate
PROCESS_OF
Object
Patients
24. Low Dose Radiation Therapy TREATS Symptom severe
Subject
Low Dose Radiation Therapy
Predicate
TREATS
Object
Symptom severe
ABSTRACT

PURPOSE:

The respiratory disease COVID-19 reached global pandemic status in 2020. Excessive inflammation is believed to result in the most severe symptoms and death from this disease. Because treatment options for patients with severe COVID-19 related pulmonary symptoms remain limited, whole-lung low-dose radiation therapy is being evaluated as an anti-inflammatory modality. However, there is concern about the long-term risks associated with low-dose pulmonary irradiation. To help quantify the benefit-risk balance of low-dose radiation therapy for COVID-19, we estimated radiation-induced lifetime risks of both lung cancer and heart disease (major coronary events) for patients of different sexes, treated at ages 50 to 85, with and without other relevant risk factors (cigarette smoking and baseline heart disease risk). METHODS AND MATERIALS These estimates were generated by combining state-of-the-art radiation risk models for lung cancer and for heart disease together with background lung cancer and heart disease risks and age/sex-dependent survival probabilities for the U.S.

RESULTS:

Estimated absolute radiation-induced risks were generally higher for lung cancer compared with major coronary events. The highest estimated lifetime radiation-induced lung cancer risks were approximately 6% for female smokers treated between ages 50 and 60. The highest estimated radiation-induced heart disease risks were approximately 3% for males or females with high heart disease risk factors and treated between ages 50 and 60.

CONCLUSIONS:

The estimated summed lifetime risk of lung cancer and major coronary events reached up to 9% in patients with high baseline risk factors. Predicted lung cancer and heart disease risks were lowest in older nonsmoking patients and patients with few cardiac risk factors. These long-term risk estimates, along with consideration of possible acute reactions, should be useful in assessing the benefit-risk balance for low-dose radiation therapy to treat severe COVID-19 pulmonary symptoms, and suggest that background risk factors, particularly smoking, should be taken into account in such assessments.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Radiation Dosage / COVID-19 / Heart Diseases / Lung / Lung Neoplasms / Neoplasms, Radiation-Induced Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Int J Radiat Oncol Biol Phys Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Radiation Dosage / COVID-19 / Heart Diseases / Lung / Lung Neoplasms / Neoplasms, Radiation-Induced Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Int J Radiat Oncol Biol Phys Year: 2021 Document Type: Article