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Maternal death related to COVID-19: A systematic review and meta-analysis focused on maternal co-morbidities and clinical characteristics.
La Verde, Marco; Riemma, Gaetano; Torella, Marco; Cianci, Stefano; Savoia, Fabiana; Licciardi, Federico; Scida, Serena; Morlando, Maddalena; Colacurci, Nicola; De Franciscis, Pasquale.
  • La Verde M; Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Riemma G; Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Torella M; Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Cianci S; Dipartimento di Ginecologia Oncologica e Chirurgia Ginecologica Miniinvasiva, Policlinico G. Martino, Università degli studi di Messina, Messina, Italy.
  • Savoia F; Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Licciardi F; Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Scida S; Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Morlando M; Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Colacurci N; Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • De Franciscis P; Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Int J Gynaecol Obstet ; 154(2): 212-219, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1209518
ABSTRACT

BACKGROUND:

Besides reducing the quality of obstetric care, the direct impact of COVID-19 on pregnancy and postpartum is uncertain.

OBJECTIVE:

To evaluate the characteristics of pregnant women who died due to COVID-19. SEARCH STRATEGY Cochrane Library, Embase, MEDLINE, Scopus, and Google Scholar were searched from inception to February 2021. SELECTION CRITERIA Studies that compared deceased and survived pregnant women with COVID-19. DATA COLLECTION AND

ANALYSIS:

Relevant data were extracted and tabulated. The primary outcome was maternal co-morbidity. MAIN

RESULTS:

Thirteen studies with 154 deceased patients were included. Obesity doubled the risk of death (relative risk [RR] 2.48, 95% confidence interval [CI] 1.41-4.36, I2  = 0%). No differences were found for gestational diabetes (RR 5.71; 95% CI 0.77-42.44, I2  = 94%) or asthma (RR 2.05, 95% CI 0.81-5.15, I2  = 0%). Overall, at least one severe co-morbidity showed a twofold increased risk of death (RR 2.26, 95% CI 1.77-2.89, I2  = 76%). Admission to intensive care was related to a fivefold increased risk of death (RR 5.09, 95% CI 2.00-12.98, I2  = 56%), with no difference in need for respiratory support (RR 0.53, 95% CI 0.23-1.48, I2  = 95%) or mechanical ventilation (RR 4.34, 95% CI 0.96-19.60, I2  = 58%).

CONCLUSION:

COVID-19 with at least one co-morbidity increases risk of intensive care and mortality.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Maternal Mortality / Maternal Death / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Int J Gynaecol Obstet Year: 2021 Document Type: Article Affiliation country: Ijgo.13726

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Maternal Mortality / Maternal Death / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Int J Gynaecol Obstet Year: 2021 Document Type: Article Affiliation country: Ijgo.13726