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Predictive factors of mortality in patients with COVID-19 in Guinea: analysis of the first 140 cases admitted to intensive care unit.
Donamou, Joseph; Touré, Abdoulaye; Camara, Amadou Yalla; Camara, Djiki; Camara, M'mah Lamine; Traoré, Abdourhamane Dine; Camara, Mariame Mohamed; Bangoura, Almamy; Dramé, Boubacar Atigou; Sossa, Luc Kouessi; Abékan, Jean-Marc Roméo; Edemessi, Axel Irvin; Saliou, Sow Mamadou.
  • Donamou J; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service of the Donka National Hospital Conakry, Conakry, Guinea.
  • Touré A; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service, Ignace Deen National Hospital Conakry, Conakry, Guinea.
  • Camara AY; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service of the Donka National Hospital Conakry, Conakry, Guinea.
  • Camara D; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service of the Donka National Hospital Conakry, Conakry, Guinea.
  • Camara ML; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service of the Donka National Hospital Conakry, Conakry, Guinea.
  • Traoré AD; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service of the Donka National Hospital Conakry, Conakry, Guinea.
  • Camara MM; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service, Ignace Deen National Hospital Conakry, Conakry, Guinea.
  • Bangoura A; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service, Ignace Deen National Hospital Conakry, Conakry, Guinea.
  • Dramé BA; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service, Ignace Deen National Hospital Conakry, Conakry, Guinea.
  • Sossa LK; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service of the Donka National Hospital Conakry, Conakry, Guinea.
  • Abékan JR; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service of the Donka National Hospital Conakry, Conakry, Guinea.
  • Edemessi AI; Gamal Abdel Nasser University of Conakry, Anaesthesia and Intensive Care Service of the Donka National Hospital Conakry, Conakry, Guinea.
  • Saliou SM; Gamal Abdel Nasser University of Conakry, Infectious and Tropical Diseases Department of the Donka National Hospital, Conakry, Guinea.
Pan Afr Med J ; 38: 205, 2021.
Article in English | MEDLINE | ID: covidwho-1209790
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. intensive care unit LOCATION_OF Cross-Sectional Studies
Subject
intensive care unit
Predicate
LOCATION_OF
Object
Cross-Sectional Studies
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. intensive care unit LOCATION_OF Cross-Sectional Studies
Subject
intensive care unit
Predicate
LOCATION_OF
Object
Cross-Sectional Studies
ABSTRACT

INTRODUCTION:

the objective was to identify the predictive factors contributing to COVID-related deaths in Intensive Care Unit.

METHODS:

this was a 4-month (12th March to 12th July 2020) cross sectional study carried out in the intensive care unit of the COVID treatment center of Donka National Hospital, the only hospital with a COVID intensive care unit in Guinea.

RESULTS:

during our period of study 140 patients were hospitalized in the COVID intensive care unit and 35 patients died (25%). In univariate analysis, the occurrence of death was associated with confusional syndrome (p<0.001), time to admission (p<0.001), use of an inotropic or vasopressor (p<0.001), Brescia score ≥ 2 (p=0.004), non-invasive ventilation (p=0.011), stroke (p=0.014), Acute Respiratory Distress Syndrome (ARDS) (p=0.015), male (p=0.021), provenance (p=0.021), acute renal failure (p=0.022), pulmonary embolism (p=0.022), invasive ventilation (p=0.022), and age > 60 years (p=0.047). In multivariate analysis, the factors predictive of mortality were Acute Respiratory Distress Syndrome (ARDS) (OR= 6.33, 95% CI [1.66-29]; p=0.007), a Brescia score ≥ 2 (OR =5.8, 95% CI [1.7-19.2]; p=0.004) and admission delay (OR =5.6, 95% CI [1.8-17.5]; p=0.003).

CONCLUSION:

our study shows that the acute respiratory distress syndrome, then the Brescia score ≥ 2, and finally the time to admission to intensive care were all associated with an increased risk of death for patients. These results are different from those reported in Asia, Europe and North America.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 / Intensive Care Units Type of study: Etiology study / Prevalence study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Africa Language: English Journal: Pan Afr Med J Year: 2021 Document Type: Article Affiliation country: Pamj.2021.38.205.27078

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 / Intensive Care Units Type of study: Etiology study / Prevalence study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Africa Language: English Journal: Pan Afr Med J Year: 2021 Document Type: Article Affiliation country: Pamj.2021.38.205.27078