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Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose.
Reynolds, Catherine J; Pade, Corinna; Gibbons, Joseph M; Butler, David K; Otter, Ashley D; Menacho, Katia; Fontana, Marianna; Smit, Angelique; Sackville-West, Jane E; Cutino-Moguel, Teresa; Maini, Mala K; Chain, Benjamin; Noursadeghi, Mahdad; Brooks, Tim; Semper, Amanda; Manisty, Charlotte; Treibel, Thomas A; Moon, James C; Valdes, Ana M; McKnight, Áine; Altmann, Daniel M; Boyton, Rosemary.
  • Reynolds CJ; Department of Infectious Disease, Imperial College London, London, UK.
  • Pade C; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Gibbons JM; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Butler DK; Department of Infectious Disease, Imperial College London, London, UK.
  • Otter AD; National Infection Service, Public Health England, Porton Down, UK.
  • Menacho K; St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Fontana M; Royal Free London NHS Foundation Trust, London, UK.
  • Smit A; Division of Medicine, University College London, London, UK.
  • Sackville-West JE; Royal Free London NHS Foundation Trust, London, UK.
  • Cutino-Moguel T; James Wigg Practice, Kentish Town, London, UK.
  • Maini MK; St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Chain B; Division of Infection and Immunity, University College London, London, UK.
  • Noursadeghi M; Division of Infection and Immunity, University College London, London, UK.
  • Semper A; National Infection Service, Public Health England, Porton Down, UK.
  • Manisty C; National Infection Service, Public Health England, Porton Down, UK.
  • Treibel TA; St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Moon JC; Institute of Cardiovascular Science, University College London, London, UK.
  • Valdes AM; Institute of Cardiovascular Science, University College London, London, UK.
  • McKnight Á; St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Altmann DM; Institute of Cardiovascular Science, University College London, London, UK.
Science ; 2021 Apr 30.
Article in English | MEDLINE | ID: covidwho-1209815
Semantic information from SemMedBD (by NLM)
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Vaccines
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ADMINISTERED_TO
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Health Personnel
2. Vaccines NEG_INHIBITS Immune response
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Immune response
3. Vaccines ADMINISTERED_TO Health Personnel
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Vaccines
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ADMINISTERED_TO
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Health Personnel
4. Vaccines NEG_INHIBITS Immune response
Subject
Vaccines
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NEG_INHIBITS
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Immune response
ABSTRACT
SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern. We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in healthcare workers (HCW) followed longitudinally, with or without prior Wuhan-Hu-1 SARS-CoV-2 infection. After one dose, individuals with prior infection showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351. By comparison, HCW receiving one vaccine dose without prior infection showed reduced immunity against variants. B.1.1.7 and B.1.351 spike mutations resulted in increased, abrogated or unchanged T cell responses depending on human leukocyte antigen (HLA) polymorphisms. Single dose vaccination with BNT162b2 in the context of prior infection with a heterologous variant substantially enhances neutralizing antibody responses against variants.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Language: English Year: 2021 Document Type: Article Affiliation country: Science.abh1282

Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Language: English Year: 2021 Document Type: Article Affiliation country: Science.abh1282