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Serum neurofilament light chain (sNfL) values in a large cross-sectional population of children with asymptomatic to moderate COVID-19.
Geis, Tobias; Brandstetter, Susanne; Toncheva, Antoaneta A; Laub, Otto; Leipold, Georg; Wagner, Ralf; Kabesch, Michael; Kasser, Severin; Kuhle, Jens; Wellmann, Sven.
  • Geis T; University Children's Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John, University of Regensburg, Steinmetzstr. 1-3, 93049, Regensburg, Germany.
  • Brandstetter S; University Children's Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John, University of Regensburg, Steinmetzstr. 1-3, 93049, Regensburg, Germany.
  • Toncheva AA; Research and Development Campus Regensburg (WECARE), at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.
  • Laub O; University Children's Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John, University of Regensburg, Steinmetzstr. 1-3, 93049, Regensburg, Germany.
  • Leipold G; Pediatric Office Dr. Laub, Rosenheim, Germany.
  • Wagner R; Pediatric Office Dr. Leipold, Regensburg, Germany.
  • Kabesch M; Institute of Medical Microbiology and Hygiene, Molecular Microbiology (Virology), University of Regensburg, Regensburg, Germany.
  • Kasser S; University Children's Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John, University of Regensburg, Steinmetzstr. 1-3, 93049, Regensburg, Germany.
  • Kuhle J; Research and Development Campus Regensburg (WECARE), at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.
  • Wellmann S; Department of Pediatric Hematology and Oncology, University Children´s Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
J Neurol ; 268(11): 3969-3974, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1210701
Semantic information from SemMedBD (by NLM)
1. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
2. Single-Molecule Array METHOD_OF Light chain level
Subject
Single-Molecule Array
Predicate
METHOD_OF
Object
Light chain level
3. Antibodies PART_OF Child
Subject
Antibodies
Predicate
PART_OF
Object
Child
4. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
5. Single-Molecule Array METHOD_OF Light chain level
Subject
Single-Molecule Array
Predicate
METHOD_OF
Object
Light chain level
6. Antibodies PART_OF Child
Subject
Antibodies
Predicate
PART_OF
Object
Child
ABSTRACT

BACKGROUND:

Serum neurofilament light chain (sNfL) is an established biomarker of neuro-axonal damage in multiple neurological disorders. Raised sNfL levels have been reported in adults infected with pandemic coronavirus disease 2019 (COVID-19). Levels in children infected with COVID-19 have not as yet been reported.

OBJECTIVE:

To evaluate whether sNfL is elevated in children contracting COVID-19.

METHODS:

Between May 22 and July 22, 2020, a network of outpatient pediatricians in Bavaria, Germany, the Coronavirus antibody screening in children from Bavaria study network (CoKiBa), recruited healthy children into a cross-sectional study from two sources an ongoing prevention program for 1-14 years, and referrals of 1-17 years consulting a pediatrician for possible infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We determined sNfL levels by single molecule array immunoassay and SARS-CoV-2 antibody status by two independent quantitative methods.

RESULTS:

Of the 2652 included children, 148 (5.6%) were SARS-CoV-2 antibody positive with asymptomatic to moderate COVID-19 infection. Neurological symptoms-headache, dizziness, muscle aches, or loss of smell and taste-were present in 47/148 cases (31.8%). Mean sNfL levels were 5.5 pg/ml (SD 2.9) in the total cohort, 5.1 (SD 2.1) pg/ml in the children with SARS-CoV-2 antibodies, and 5.5 (SD 3.0) pg/ml in those without. Multivariate regression analysis revealed age-but neither antibody status, antibody levels, nor clinical severity-as an independent predictor of sNfL. Follow-up of children with pediatric multisystem inflammatory syndrome (n = 14) showed no association with sNfL.

CONCLUSIONS:

In this population study, children with asymptomatic to moderate COVID-19 showed no neurochemical evidence of neuronal damage.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Intermediate Filaments / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Child / Humans Language: English Journal: J Neurol Year: 2021 Document Type: Article Affiliation country: S00415-021-10554-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Intermediate Filaments / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Child / Humans Language: English Journal: J Neurol Year: 2021 Document Type: Article Affiliation country: S00415-021-10554-1