Does vitamin D serum level affect prognosis of COVID-19 patients?
Int J Infect Dis
; 107: 264-267, 2021 Jun.
Article
in English
| MEDLINE | ID: covidwho-1210963
ABSTRACT
BACKGROUND:
Since the beginning of the Coronavirus disease 2019 (COVID-19) pandemic there have been contradictions and speculations about the relationship between vitamin D and COVID-19. Given that there is an association between vitamin D deficiency and some diseases - including cancer, autoimmune disease and some infectious diseases - a higher incidence and mortality rate in the vitamin-D-deficient COVID-19 population was not a surprise; conversely, some research would argue this relationship. Considering these contradictions, this study aimed to determine the relationship between prognosis and vitamin D level in cases with COVID-19.METHODS:
In this cross-sectional study, 329 confirmed cases of COVID-19 - who were admitted to Kamkar-ArabNia Hospital in Qom city, Iran from March-July 2020 - were categorized into three groups according to vitamin D serum levels (ng/ml) sufficient (>30), insufficient (20-30) and deficient (<20). Prognosis was determined across the groups.RESULTS:
There was a significant difference in hospital stay between patients with sufficient and insufficient vitamin D levels (P = 0.007). Adjusting vitamin D levels for confounding variables, linear regression underscored significant differences in the association between length of hospitalization and lower vitamin D levels, with a longer stay noted in insufficient groups (P = 0.002). However, there was no significant difference in the time interval to return to normal oxygen level (from SpO2 < 93%) or death rate between groups (P > 0.05).CONCLUSION:
There was a significant association between hospital stay and lower serum vitamin D levels. However, the relationship between vitamin D status and death rate or the time interval to return to normal oxygen levels was not significant.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vitamin D
/
SARS-CoV-2
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Language:
English
Journal:
Int J Infect Dis
Journal subject:
Communicable Diseases
Year:
2021
Document Type:
Article
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