Coronavirus disease 2019 respiratory disease in children: clinical presentation and pathophysiology.
Curr Opin Pediatr
; 33(3): 302-310, 2021 06 01.
Article
in English
| MEDLINE | ID: covidwho-1211436
ABSTRACT
PURPOSE OF REVIEW Pediatric coronavirus disease 2019 (COVID-19) respiratory disease is a distinct entity from adult illness, most notable in its milder phenotype. This review summarizes the current knowledge of the clinical patterns, cellular pathophysiology, and epidemiology of COVID-19 respiratory disease in children with specific attention toward factors that account for the maturation-related differences in disease severity. RECENT FINDINGS:
Over the past 14 months, knowledge of the clinical presentation and pathophysiology of COVID-19 pneumonia has rapidly expanded. The decreased disease severity of COVID-19 pneumonia in children was an early observation. Differences in the efficiency of viral cell entry and timing of immune recognition and response between children and adults remain at the center of ongoing research.SUMMARY:
The clinical spectrum of COVID-19 respiratory disease in children is well defined. The age-related differences protecting children from severe disease and death remain incompletely understood.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiration Disorders
/
Respiratory Tract Diseases
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Child
/
Humans
Language:
English
Journal:
Curr Opin Pediatr
Journal subject:
Pediatrics
Year:
2021
Document Type:
Article
Affiliation country:
MOP.0000000000001013
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