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Analysis of laboratory blood parameter results for patients diagnosed with COVID-19, from all ethnic group populations: A single centre study.
Marwah, Mandeep; Marwah, Sukhjinder; Blann, Andrew; Morrissey, Hana; Ball, Patrick; Wandroo, Farooq A.
  • Marwah M; Aston University, Birmingham, UK.
  • Marwah S; Department of Haematology, Sandwell and West Birmingham Hospitals, NHS Trust, West Bromwich, UK.
  • Blann A; The Institute of Biomedical Science, London, UK.
  • Morrissey H; University of Wolverhampton, Wolverhampton, UK.
  • Ball P; University of Wolverhampton, Wolverhampton, UK.
  • Wandroo FA; Department of Haematology, Sandwell and West Birmingham Hospitals, NHS Trust, West Bromwich, UK.
Int J Lab Hematol ; 43(5): 1243-1251, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1211529
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

INTRODUCTION:

Although factors such as age, sex, diabetes, obesity and changes in certain laboratory investigations are important prognostic factors in COVID-19 infection, these may not apply to all ethnic/racial groups. We hypothesized differences in routine biochemistry and haematology indices in Caucasian and a combined group of Black, Asian and Minority Ethnic (BAME) patients who tested positive for COVID-19 who died, compared to survivors.

METHODS:

We tested our hypothesis in 445 patients (229 Caucasian, 216 BAME) admitted to secondary care with proven COVID-19 infection, in whom standard routine laboratory indices were collected on admission.

RESULTS:

After 28 weeks, 190 (42.7%) had died within 28 days of COVID diagnosis (97 Caucasians [42.4%], 93 BAMEs [43.1%], P = .923). A general linear model analysis found the ethnicity interaction with mortality to be significant for fibrinogen, ferritin and HbA1 c (after controlling for age). In a multivariate analysis, a neutrophil/lymphocyte ratio > 7.4 and a urea/albumin ratio > 0.28 increased the odds of death for both the Caucasian and the BAME group. Additional factors increasing the odds ratio in the BAME group included age >60 years and being diabetic.

CONCLUSION:

Neutrophil/lymphocyte ratio and urea/albumin ratio are simple metrics that predict death to aid clinicians in determining the prognosis of COVID-19 and help provide early intensive intervention to reduce mortality. In the BAME groups, intensive monitoring even at younger age and those with diabetes may also help reduce COVID-19 associated mortality.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Controlled clinical trial / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Variants Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Int J Lab Hematol Journal subject: Hematology Year: 2021 Document Type: Article Affiliation country: Ijlh.13538

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Controlled clinical trial / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Variants Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Int J Lab Hematol Journal subject: Hematology Year: 2021 Document Type: Article Affiliation country: Ijlh.13538