Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis.
PLoS One
; 16(5): e0250602, 2021.
Article
in English
| MEDLINE | ID: covidwho-1211717
ABSTRACT
OBJECTIVE:
We aimed to systematically identify the possible risk factors responsible for severe cases.METHODS:
We searched PubMed, Embase, Web of science and Cochrane Library for epidemiological studies of confirmed COVID-19, which include information about clinical characteristics and severity of patients' disease. We analyzed the potential associations between clinical characteristics and severe cases.RESULTS:
We identified a total of 41 eligible studies including 21060 patients with COVID-19. Severe cases were potentially associated with advanced age (Standard Mean Difference (SMD) = 1.73, 95% CI 1.34-2.12), male gender (Odds Ratio (OR) = 1.51, 95% CI1.33-1.71), obesity (OR = 1.89, 95% CI 1.44-2.46), history of smoking (OR = 1.40, 95% CI1.06-1.85), hypertension (OR = 2.42, 95% CI 2.03-2.88), diabetes (OR = 2.40, 95% CI 1.98-2.91), coronary heart disease (OR 2.87, 95% CI 2.22-3.71), chronic kidney disease (CKD) (OR = 2.97, 95% CI 1.63-5.41), cerebrovascular disease (OR = 2.47, 95% CI 1.54-3.97), chronic obstructive pulmonary disease (COPD) (OR = 2.88, 95% CI 1.89-4.38), malignancy (OR = 2.60, 95% CI 2.00-3.40), and chronic liver disease (OR = 1.51, 95% CI 1.06-2.17). Acute respiratory distress syndrome (ARDS) (OR = 39.59, 95% CI 19.99-78.41), shock (OR = 21.50, 95% CI 10.49-44.06) and acute kidney injury (AKI) (OR = 8.84, 95% CI 4.34-18.00) were most likely to prevent recovery. In summary, patients with severe conditions had a higher rate of comorbidities and complications than patients with non-severe conditions.CONCLUSION:
Patients who were male, with advanced age, obesity, a history of smoking, hypertension, diabetes, malignancy, coronary heart disease, hypertension, chronic liver disease, COPD, or CKD are more likely to develop severe COVID-19 symptoms. ARDS, shock and AKI were thought to be the main hinderances to recovery.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Comorbidity
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Language:
English
Journal:
PLoS One
Journal subject:
Science
/
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
Journal.pone.0250602
Similar
MEDLINE
...
LILACS
LIS