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Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU
Çalik Basaran, Nursel; Uyaroglu, Oguz Abdullah; Telli Dizman, Gülçin; Özisik, Lale; Sahin, Taha Koray; Tas, Zahit; Inkaya, Ahmet Çagkan; Karahan, Sevilay; Alp, Sehnaz; Alp, Alpaslan; Metan, Gökhan; Zarakol, Pinar; Sain Güven, Gülay; Öz, Serife Gül; Topeli, Arzu; Uzun, Ömrüm; Akova, Murat; Ünal, Serhat.
  • Çalik Basaran N; Department of Internal Medicine, General Internal Medicine Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Uyaroglu OA; Department of Internal Medicine, General Internal Medicine Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Telli Dizman G; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Özisik L; Department of Internal Medicine, General Internal Medicine Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Sahin TK; Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Tas Z; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Inkaya AÇ; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Karahan S; Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Alp S; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Alp A; Department of Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Metan G; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Zarakol P; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Sain Güven G; Department of Internal Medicine, General Internal Medicine Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Öz SG; Department of Internal Medicine, General Internal Medicine Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Topeli A; Department of Internal Medicine, Intensive Care Division, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Uzun Ö; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Akova M; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
  • Ünal S; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Turk J Med Sci ; 51(2): 411-420, 2021 04 30.
Article in English | MEDLINE | ID: covidwho-1211945
ABSTRACT
Background/

aim:

Despite the fact that the COVID-19 pandemic has been going on for over 5 months, there is yet to be a standard management policy for all patients including those with mild-to-moderate cases. We evaluated the role of early hospitalization in combination with early antiviral therapy with COVID-19 patients in a tertiary care university hospital. Materials and

methods:

This was a prospective, observational, single-center study on probable/confirmed COVID-19 patients hospitalized in a tertiary care hospital on COVID-19 wards between March 20 and April 30, 2020. The demographic, laboratory, and clinical data were collected.

Results:

We included 174 consecutive probable/confirmed COVID-19 adult patients hospitalized in the Internal Medicine wards of the University Adult Hospital between March 20 and April 30, 2020. The median age was 45.5 (19­92) years and 91 patients (52.3%) were male. One hundred and twenty (69%) were confirmed microbiologically, 41 (23.5%) were radiologically diagnosed, and 13 (7.5%) were clinically suspected (negative microbiological and radiological findings compatible with COVID-19); 35 (20.1%) had mild, 107 (61.5%) moderate disease, and 32 (18.4%) had severe pneumonia. Out of 171 cases, 130 (74.3%) showed pneumonia; 80 were typical, and 50 showed indeterminate infiltration for COVID-19. Patients were admitted within a median of 3 days (0-14 days) after symptoms appear. The median duration of hospitalization was 4 days (0-28 days). In this case series, 13.2% patients were treated with hydroxychloroquine alone, 64.9% with hydroxychloroquine plus azithromycin, and 18.4% with regimens including favipiravir. A total of 15 patients (8.5%) were transferred to the ICU. Four patients died (2.2%).

Conclusion:

In our series, 174 patients were admitted to the hospital wards for COVID-19, 69% were confirmed with PCR and/or antibody test. At the time of admission, nearly one fifth of the patients had severe diseases. Of the patients, 95.4% received hydroxychloroquine alone or in combination. The overall case fatality rate was 2.2%.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pyrazines / Azithromycin / Amides / COVID-19 Drug Treatment / Hospitalization / Hydroxychloroquine / Anti-Bacterial Agents Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Turk J Med Sci Year: 2021 Document Type: Article Affiliation country: Sag-2006-173

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pyrazines / Azithromycin / Amides / COVID-19 Drug Treatment / Hospitalization / Hydroxychloroquine / Anti-Bacterial Agents Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Turk J Med Sci Year: 2021 Document Type: Article Affiliation country: Sag-2006-173