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Low prevalence of asthma in Mexican children and adults with a positive rtRT-PCR test for SARS-CoV-2: a cross-sectional study during the 2020 pandemic.
Bedolla-Barajas, Martín; Morales-Romero, Jaime; Bedolla-Pulido, Tonatiuh Ramses; Meza-López, Carlos; Robles-Figueroa, Martín; Pulido-Guillén, Norma Angélica; Orozco-Alatorre, Luis Gustavo; Andrade-Castellanos, Carlos Alberto.
  • Bedolla-Barajas M; Servicio de Alergia e Inmunología Clínica, Nuevo Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Guadalajara, México; drmbedbar@gmail.com.
  • Morales-Romero J; Instituto de Salud Pública, Universidad Veracruzana, Veracruz, México.
  • Bedolla-Pulido TR; Servicio de Pediatría, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Guadalajara, México.
  • Meza-López C; Servicio de Pediatría, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Guadalajara, México.
  • Robles-Figueroa M; Servicio de Medicina Interna, Nuevo Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Guadalajara, México.
  • Pulido-Guillén NA; Psicología Clínica, Guadalajara, México.
  • Orozco-Alatorre LG; Servicio de Pediatría, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Guadalajara, México.
  • Andrade-Castellanos CA; Servicio de Medicina Interna, Nuevo Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Guadalajara, México.
Allergol Immunopathol (Madr) ; 49(3): 1-7, 2021.
Article in English | MEDLINE | ID: covidwho-1212097
ABSTRACT

BACKGROUND:

It has recently been argued that asthma does not increase the risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. If so, the prevalence of asthma in subjects diagnosed with COVID-19 should be lower than in the general population.

OBJECTIVE:

To determine the prevalence of asthma in Mexican children and adults with SARS-CoV-2 infection.

METHODS:

A public database of the Epidemiological Surveillance System for Viral Respiratory Disease in Mexico was analyzed. Those who underwent the real-time reverse transcriptase-polymerase chain reaction-SARS-CoV-2 (rtRT-PCR-SARS-CoV-2) test from February 27 to June 21, 2020, were included. In addition to the prevalence of asthma, some factors associated with it were investigated.

RESULTS:

Data from 417,366 subjects were analyzed. Asthma prevalence in children, adults, and global were 3.7%, 3.3%, and 3.3%, respectively. Although the asthma prevalence was lower in SARS-CoV-2 positive over negative patients, significant differences were only found in adults (2.8% vs. 3.7% respectively; odds ratio (OR) = 0.74; 95% confidence interval (CI) 0.71-0.77); but not in children (3.5% vs. 3.8%, respectively; OR = 0.91; 95%CI 0.76-1.10). Multivariate analysis showed in younger than 18 years that girls and immunosuppression were factors associated with a decrease in the odds to develop asthma. In adults, asthma was positively associated with females, obesity, smoking, immunosuppression, chronic obstructive pulmonary disease, arterial hypertension, and cardiovascular disease.

CONCLUSION:

The prevalence of asthma in child and adult were lower than those previously reported. Our study seems to support the hypothesis that asthma patients have a lower risk of SARS-CoV-2 infection. Further studies are required to demonstrate the consistency of our findings.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Pandemics / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Mexico Language: English Journal: Allergol Immunopathol (Madr) Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Pandemics / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Mexico Language: English Journal: Allergol Immunopathol (Madr) Year: 2021 Document Type: Article