In Vitro Models for Studying Respiratory Host-Pathogen Interactions.
Adv Biol (Weinh)
; 5(6): e2000624, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1212314
ABSTRACT
Respiratory diseases and lower respiratory tract infections are among the leading cause of death worldwide and, especially given the recent severe acute respiratory syndrome coronavirus-2 pandemic, are of high and prevalent socio-economic importance. In vitro models, which accurately represent the lung microenvironment, are of increasing significance given the ethical concerns around animal work and the lack of translation to human disease, as well as the lengthy time to market and the attrition rates associated with clinical trials. This review gives an overview of the biological and immunological components involved in regulating the respiratory epithelium system in health, disease, and infection. The evolution from 2D to 3D cell biology and to more advanced technological integrated models for studying respiratory host-pathogen interactions are reviewed and provide a reference point for understanding the in vitro modeling requirements. Finally, the current limitations and future perspectives for advancing this field are presented.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Host-Pathogen Interactions
/
SARS-CoV-2
/
COVID-19
/
Models, Biological
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Adv Biol (Weinh)
Year:
2021
Document Type:
Article
Affiliation country:
Adbi.202000624
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