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In Vitro Models for Studying Respiratory Host-Pathogen Interactions.
Barron, Sarah L; Saez, Janire; Owens, Róisín M.
  • Barron SL; Bioassay Impurities and Quality, Biopharmaceuticals Development, R&D, AstraZeneca, Cambridge, CB21 6GP, UK.
  • Saez J; Department of Chemical Engineering and Biotechnology, Philippa Fawcett Drive, Cambridge, CB3 0AS, UK.
  • Owens RM; Department of Chemical Engineering and Biotechnology, Philippa Fawcett Drive, Cambridge, CB3 0AS, UK.
Adv Biol (Weinh) ; 5(6): e2000624, 2021 06.
Article in English | MEDLINE | ID: covidwho-1212314
ABSTRACT
Respiratory diseases and lower respiratory tract infections are among the leading cause of death worldwide and, especially given the recent severe acute respiratory syndrome coronavirus-2 pandemic, are of high and prevalent socio-economic importance. In vitro models, which accurately represent the lung microenvironment, are of increasing significance given the ethical concerns around animal work and the lack of translation to human disease, as well as the lengthy time to market and the attrition rates associated with clinical trials. This review gives an overview of the biological and immunological components involved in regulating the respiratory epithelium system in health, disease, and infection. The evolution from 2D to 3D cell biology and to more advanced technological integrated models for studying respiratory host-pathogen interactions are reviewed and provide a reference point for understanding the in vitro modeling requirements. Finally, the current limitations and future perspectives for advancing this field are presented.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 / Models, Biological Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Adv Biol (Weinh) Year: 2021 Document Type: Article Affiliation country: Adbi.202000624

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 / Models, Biological Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Adv Biol (Weinh) Year: 2021 Document Type: Article Affiliation country: Adbi.202000624