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Acute symptomatic seizures and COVID-19: Hospital-based study.
Khedr, Eman M; Shoyb, Ahmed; Mohammaden, Mahmoud; Saber, Mostafa.
  • Khedr EM; Department of Neuropsychiatry, Faculty of Medicine, Assiut University, Egypt. Electronic address: emankhedr99@yahoo.com.
  • Shoyb A; Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Egypt.
  • Mohammaden M; Department of Neuropsychiatry, Faculty of Medicine, South Valley University, Egypt.
  • Saber M; Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Egypt.
Epilepsy Res ; 174: 106650, 2021 08.
Article in English | MEDLINE | ID: covidwho-1213222
ABSTRACT
BACKGROUND AND

PURPOSE:

Post COVID-19 seizures are relatively rare. The aim of the present study was to estimate the frequency of acute symptomatic seizures among patients with COVID-19 and to discuss possible pathophysiological mechanisms. MATERIAL AND

METHODS:

Out of 439 cases with COVID-19 that were admitted to Assiut and Aswan University hospitals during the period from 1 June to 10 August 2020, 19 patients (4.3 %) presented with acute symptomatic seizures. Each patient underwent computed tomography (CT) or magnetic resonance imaging (MRI) of the brain and conventional electroencephalography (EEG). Laboratory investigations included blood gases, complete blood picture, serum D-Dimer, Ferritin, C-reactive protein, renal and liver functions, and coagulation profile.

RESULTS:

Of the 19 patients, 3 had new onset seizures without underlying pathology (0.68 % out of the total 439 patients); 2 others (0.46 %) had previously diagnosed controlled epilepsy with breakthrough seizures. The majority of cases (14 patients, 3.19 %) had primary pathology that could explain the occurrence of seizures 5 suffered a post COVID-19 stroke (3 ischemic and 2 hemorrhagic stroke); 6 patients had COVID-related encephalitis; 2 patients were old ischemic stroke patients; 1 patient had a brain tumor and developed seizures post COVID-19.

CONCLUSION:

acute symptomatic seizure is not a rare complication of post COVID-19 infection. Both new onset seizures and seizures secondary to primary brain insult (post COVID encephalitis or recent stroke) were observed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Seizures / Encephalitis, Viral / Stroke / Epilepsy / COVID-19 Type of study: Experimental Studies / Observational study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Africa Language: English Journal: Epilepsy Res Journal subject: Brain / Neurology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Seizures / Encephalitis, Viral / Stroke / Epilepsy / COVID-19 Type of study: Experimental Studies / Observational study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Africa Language: English Journal: Epilepsy Res Journal subject: Brain / Neurology Year: 2021 Document Type: Article