Acute symptomatic seizures and COVID-19: Hospital-based study.
Epilepsy Res
; 174: 106650, 2021 08.
Article
in English
| MEDLINE | ID: covidwho-1213222
ABSTRACT
BACKGROUND AND PURPOSE:
Post COVID-19 seizures are relatively rare. The aim of the present study was to estimate the frequency of acute symptomatic seizures among patients with COVID-19 and to discuss possible pathophysiological mechanisms. MATERIAL ANDMETHODS:
Out of 439 cases with COVID-19 that were admitted to Assiut and Aswan University hospitals during the period from 1 June to 10 August 2020, 19 patients (4.3 %) presented with acute symptomatic seizures. Each patient underwent computed tomography (CT) or magnetic resonance imaging (MRI) of the brain and conventional electroencephalography (EEG). Laboratory investigations included blood gases, complete blood picture, serum D-Dimer, Ferritin, C-reactive protein, renal and liver functions, and coagulation profile.RESULTS:
Of the 19 patients, 3 had new onset seizures without underlying pathology (0.68 % out of the total 439 patients); 2 others (0.46 %) had previously diagnosed controlled epilepsy with breakthrough seizures. The majority of cases (14 patients, 3.19 %) had primary pathology that could explain the occurrence of seizures 5 suffered a post COVID-19 stroke (3 ischemic and 2 hemorrhagic stroke); 6 patients had COVID-related encephalitis; 2 patients were old ischemic stroke patients; 1 patient had a brain tumor and developed seizures post COVID-19.CONCLUSION:
acute symptomatic seizure is not a rare complication of post COVID-19 infection. Both new onset seizures and seizures secondary to primary brain insult (post COVID encephalitis or recent stroke) were observed.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Seizures
/
Encephalitis, Viral
/
Stroke
/
Epilepsy
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
Topics:
Long Covid
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Africa
Language:
English
Journal:
Epilepsy Res
Journal subject:
Brain
/
Neurology
Year:
2021
Document Type:
Article
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