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Comparative analysis of antibodies to SARS-CoV-2 between asymptomatic and convalescent patients.
Dwyer, Connor J; Cloud, Colleen A; Wang, Cindy; Heidt, Philip; Chakraborty, Paramita; Duke, Tara F; McGue, Shannon; Jeffcoat, Braxton; Dunne, Jaclyn; Johnson, Logan; Choi, Seungho; Nahhas, Georges J; Gandy, Amy S; Babic, Nikolina; Nolte, Frederick S; Howe, Philip; Ogretmen, Besim; Gangaraju, Vamsi K; Tomlinson, Stephen; Madden, Brian; Bridges, Tracy; Flume, Patrick A; Wrangle, John; Rubinstein, Mark P; Baliga, Prabhakar K; Nadig, Satish N; Mehrotra, Shikhar.
  • Dwyer CJ; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Cloud CA; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Wang C; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Heidt P; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Chakraborty P; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Duke TF; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • McGue S; Department of Medicine, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Jeffcoat B; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Dunne J; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Johnson L; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Choi S; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Nahhas GJ; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Gandy AS; Clinical and Translational Research Center,Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Babic N; Laboratory and Pathology Medicine, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Nolte FS; Laboratory and Pathology Medicine, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Howe P; Biochemistry and Molecular Biology, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Ogretmen B; Biochemistry and Molecular Biology, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Gangaraju VK; Biochemistry and Molecular Biology, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Tomlinson S; Microbiology & Immunology, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Madden B; The Blood Connection, 1099 Bracken Road, Piedmont, SC 29673, USA.
  • Bridges T; The Blood Connection, 1099 Bracken Road, Piedmont, SC 29673, USA.
  • Flume PA; Department of Medicine, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Wrangle J; Department of Medicine, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Rubinstein MP; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Baliga PK; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Nadig SN; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
  • Mehrotra S; Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA.
iScience ; 24(6): 102489, 2021 Jun 25.
Article in English | MEDLINE | ID: covidwho-1213295
ABSTRACT
The SARS-CoV-2 viral pandemic has induced a global health crisis, which requires more in-depth investigation into immunological responses to develop effective treatments and vaccines. To understand protective immunity against COVID-19, we screened over 60,000 asymptomatic individuals in the Southeastern United States for IgG antibody positivity against the viral Spike protein, and approximately 3% were positive. Of these 3%, individuals with the highest anti-S or anti-RBD IgG level showed a strong correlation with inhibition of ACE2 binding and cross-reactivity against non-SARS-CoV-2 coronavirus S-proteins. We also analyzed samples from 94 SARS-CoV-2 patients and compared them with those of asymptomatic individuals. SARS-CoV-2 symptomatic patients had decreased antibody responses, ACE2 binding inhibition, and antibody cross-reactivity. Our study shows that healthy individuals can mount robust immune responses against SARS-CoV-2 without symptoms. Furthermore, IgG antibody responses against S and RBD may correlate with high inhibition of ACE2 binding in individuals tested for SARS-CoV-2 infection or post vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Topics: Vaccines Language: English Journal: IScience Year: 2021 Document Type: Article Affiliation country: J.isci.2021.102489

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Topics: Vaccines Language: English Journal: IScience Year: 2021 Document Type: Article Affiliation country: J.isci.2021.102489