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A recommended paradigm for vaccination of rheumatic disease patients with the SARS-CoV-2 vaccine.
Moutsopoulos, Haralampos M.
  • Moutsopoulos HM; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens and Academy of Athens, Athens, Greece. Electronic address: hmoutsop@med.uoa.gr.
J Autoimmun ; 121: 102649, 2021 07.
Article in English | MEDLINE | ID: covidwho-1213324
ABSTRACT
Autoimmune and autoinflammatory rheumatic disorders (ARD) are treated with antimetabolites, calcineurin inhibitors and biologic agents either neutralizing cytokines [Tumor Necrosis Factor (TNF), Interleukin (IL)-1, IL-6, IL-17, B-cell activating factor] or being directed against B-cells (anti-CD-20), costimulatory molecules or JAK kinases. Similarly for the influenza or pneumococcal vaccines, there is limited data on the effectiveness of vaccination against SARS-CoV-2 infection and COVID-19 prevention for this susceptible patient population. Moreover, preliminary data from vaccinated organ transplanted, inflammatory bowel and connective tissue disease patients suggests only limited immunogenicity after the first vaccine dose, particularly in patients on immunosuppressive regimens. Herein a set of recommendations for the vaccination of immune suppressed patients with the SARS-CoV-2 vaccines is proposed aimed at achieving optimal vaccine benefit without interfering with disease activity status. Moreover, rare autoimmune adverse events related to vaccinations are discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rheumatic Diseases / Immunosuppression Therapy / Vaccination / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: J Autoimmun Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rheumatic Diseases / Immunosuppression Therapy / Vaccination / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: J Autoimmun Journal subject: Allergy and Immunology Year: 2021 Document Type: Article